{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:23:15Z","timestamp":1790428995829,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T00:00:00Z","timestamp":1141084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes is an inflammatory condition associated with iron abnormalities and increased oxidative damage. We aimed to investigate how diabetes affects the interrelationships between these pathogenic mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Glycaemic control, serum iron, proteins involved in iron homeostasis, global antioxidant capacity and levels of antioxidants and peroxidation products were measured in 39 type 1 and 67 type 2 diabetic patients and 100 control subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although serum iron was lower in diabetes, serum ferritin was elevated in type 2 diabetes (<jats:italic>p<\/jats:italic> = 0.02). This increase was not related to inflammation (C\u2010reactive protein) but inversely correlated with soluble transferrin receptors (<jats:italic>r<\/jats:italic> = \u2212 0.38, <jats:italic>p<\/jats:italic> = 0.002). Haptoglobin was higher in both type 1 and type 2 diabetes (<jats:italic>p<\/jats:italic> &lt; 0.001) and haemopexin was higher in type 2 diabetes (<jats:italic>p<\/jats:italic> &lt; 0.001). The relation between C\u2010reactive protein and haemopexin was lost in type 2 diabetes (<jats:italic>r<\/jats:italic> = 0.15, <jats:italic>p<\/jats:italic> = 0.27 <jats:italic>vs<\/jats:italic> <jats:italic>r<\/jats:italic> = 0.63, <jats:italic>p<\/jats:italic> &lt; 0.001 in type 1 diabetes and <jats:italic>r<\/jats:italic> = 0.36, <jats:italic>p<\/jats:italic> = 0.001 in controls). Haemopexin levels were independently determined by triacylglycerol (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.43) and the diabetic state (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.13). Regarding oxidative stress status, lower antioxidant concentrations were found for retinol and uric acid in type 1 diabetes, \u03b1\u2010tocopherol and ascorbate in type 2 diabetes and protein thiols in both types. These decreases were partially explained by metabolic\u2010, inflammatory\u2010 and iron alterations. An additional independent effect of the diabetic state on the oxidative stress status could be identified (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.5\u20130.14).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Circulating proteins, body iron stores, inflammation, oxidative stress and their interrelationships are abnormal in patients with diabetes and differ between type 1 and type 2 diabetes. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dmrr.635","type":"journal-article","created":{"date-parts":[[2006,2,28]],"date-time":"2006-02-28T11:49:19Z","timestamp":1141127359000},"page":"444-454","source":"Crossref","is-referenced-by-count":63,"title":["Impact of diabetes mellitus on the relationships between iron\u2010, inflammatory\u2010 and oxidative stress status"],"prefix":"10.1002","volume":"22","author":[{"given":"Ann","family":"Van Campenhout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Van Campenhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert R.","family":"Lagrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Moorkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Van Gaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Manuel\u2010y\u2010Keenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2,28]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80347-7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116482"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90013-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.39.11.1420"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.43.6.836"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(89)90061-9"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00418271"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.8.2348"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2060605"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-3886(00)00087-4"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)80626-3"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(87)90125-1"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-4622(03)00100-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/27.7.681"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7160.727"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.3.426"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.12.1978"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530120305"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199603020-00007"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(13)38014-2"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(83)90078-5"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)00117-3"},{"key":"e_1_2_6_24_2","first-page":"324","article-title":"Determination of a\u2010tocopherol in plasma, platelets and erythrocytes of type I and type II diabetic patients by HPLC","volume":"60","author":"Caye\u2010Vaugien C","year":"1990","journal-title":"Int J Vitam Nutr Res"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(89)90243-1"},{"key":"e_1_2_6_26_2","first-page":"131","volume-title":"Red Cell Metabolism; 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