{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T15:45:36Z","timestamp":1773762336212,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101073533"],"award-info":[{"award-number":["101073533"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Peripheral neuropathy (PN) is a common complication of type 2 diabetes mellitus (T2DM). In this study, we determined the independent and combined associations of T2DM and PN with device\u2010based measures of physical activity levels and sedentary behaviour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectional data from The Maastricht Study were used (\n                      <jats:italic>N<\/jats:italic>\n                      : 6471, age 59.8\u00a0\u00b1\u00a08.8). T2DM was determined with an oral glucose tolerance test and PN was, using a neurothesiometer, defined as an impaired vibration perception threshold (iVPT), that is exceeding 25\u00a0V in either one or both halluces. Physical activity and sedentary behaviour outcomes were derived through 8\u00a0days of activPAL accelerometer measurement, worn 24\u00a0h\/day. Multiple linear regression analyses were used with adjustment for demographic, lifestyle and health\u2010related indicators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the fully adjusted model, the combined presence of T2DM and iVPT presented the lowest step count (\u22121407 steps\/day [95% CI: \u22121851, \u2212963]), and showed the lowest time in light\u2010intensity (\u221227.2\u00a0min\/day [\u221238.6, \u221215.8]) and moderate\u2010to\u2010vigorous physical activity (\u22129.5\u00a0min\/day [\u221212.6, \u22126.5]). Moreover, those with both conditions had the highest sedentary time (+33.3\u00a0min\/day [21.4, 45.2]) and longest sedentary bout durations (+1.0\u00a0min\/bout [0.6, 1.4) compared with those without these conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>T2DM and PN were both independently associated with lower levels of physical activity and higher levels of sedentary time. The combination of T2DM with PN was associated with particularly low levels of physical activity and higher levels of sedentary time, indicating an additive association. Strategies to improve physical activity in these individuals should address both conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70069","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T06:50:10Z","timestamp":1753253410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Combined Associations of Type 2 Diabetes and Peripheral Neuropathy With Device\u2010Measured Physical Activity and Sedentary Behaviour\u2014The Maastricht Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5858-5517","authenticated-orcid":false,"given":"Touria","family":"Ahaouari","sequence":"first","affiliation":[{"name":"Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University  Maastricht the Netherlands"},{"name":"Care and Public Health Research Institute (CAPHRI) Maastricht University  Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Nutrition and Movement Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Berendsen","sequence":"additional","affiliation":[{"name":"Nutrition and Translational Research in Metabolism (NUTRIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Nutrition and Movement Sciences Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas","family":"Schaper","sequence":"additional","affiliation":[{"name":"Care and Public Health Research Institute (CAPHRI) Maastricht University  Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Internal Medicine Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Bosma","sequence":"additional","affiliation":[{"name":"Care and Public Health Research Institute (CAPHRI) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Social Medicine Maastricht University  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen","family":"van Greevenbroek","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Internal Medicine Maastricht University Medical Centre  Maastricht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastiaan","family":"de Galan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute Maastricht (CARIM) Maastricht University  Maastricht the Netherlands"},{"name":"Department of Internal Medicine Maastricht University Medical Centre  Maastricht the Netherlands"},{"name":"Department of internal Medicine Radboud University Medical Centre  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"T. 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