{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:49:53Z","timestamp":1781246993926,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000329","name":"Novo Nordisk UK Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Abatacept is a CTLA4\u2010Ig fusion protein that blocks CD80\/CD86\u2010dependent T\u2010cell co\u2010stimulation. When administered, Abatacept limits, to a variable degree, loss of stimulated C\u2010peptide secretion in patients with newly\u2010diagnosed type 1 diabetes (T1D), while reducing both circulating memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cells and T follicular helper (Tfh) cells; however, its precise mechanism of action is not known. To investigate this effect, we studied 12 patients, using multi\u2010parameter flow cytometry, who each self\u2010administered Abatacept in subcutaneous formulation for 6 months within 100\u00a0days of diagnosis. Abatacept treatment impacted the CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell memory compartment, inducing a reduction in T\u2010effector cells across both conventional (Tconv) and regulatory (Treg) sub\u2010populations. A reduction in activated Tfh cells (CXCR5\n                    <jats:sup>+<\/jats:sup>\n                    PD1\n                    <jats:sup>+<\/jats:sup>\n                    ICOS\n                    <jats:sup>+<\/jats:sup>\n                    ), previously described with intravenous therapy, was replicated and extended. An integrated baseline immunological phenotype predicted Abatacept\u2010induced preservation of C\u2010peptide.\n                  <\/jats:p>","DOI":"10.1002\/dmrr.70074","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T04:50:31Z","timestamp":1754974231000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subcutaneous Abatacept in New Onset Type 1 Diabetes: Clinical and Immunological Effects"],"prefix":"10.1002","volume":"41","author":[{"given":"Samuel T.","family":"Jerram","sequence":"first","affiliation":[{"name":"Blizard Institute Queen Mary University of London  London UK"},{"name":"Wolfson Diabetes and Endocrine Clinic Addenbrooke's Hospital Cambridge University Hospitals NHS Foundation Trust  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennie H. M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Immunobiology School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"National Institute for Health Research Biomedical Research Centre Guy's and St. Thomas' NHS Foundation Trust and Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Immunobiology School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"National Institute for Health Research Biomedical Research Centre Guy's and St. Thomas' NHS Foundation Trust and Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Domingo\u2010Vila","sequence":"additional","affiliation":[{"name":"Department of Immunobiology School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"National Institute for Health Research Biomedical Research Centre Guy's and St. Thomas' NHS Foundation Trust and Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuk\u2010Fun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Guy's and St. Thomas' NHS Foundation Trust  London UK"},{"name":"Department of Diabetes School of Life Course Sciences King's College London  London UK"},{"name":"Institute of Diabetes Endocrinology and Obesity King's Health Partners  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Peakman","sequence":"additional","affiliation":[{"name":"Department of Immunobiology School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"Department of Diabetes and Endocrinology Guy's and St. Thomas' NHS Foundation Trust  London UK"},{"name":"Department of Diabetes School of Life Course Sciences King's College London  London UK"},{"name":"Institute of Diabetes Endocrinology and Obesity King's Health Partners  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-1531","authenticated-orcid":false,"given":"R. David","family":"Leslie","sequence":"additional","affiliation":[{"name":"Blizard Institute Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Tree","sequence":"additional","affiliation":[{"name":"Department of Immunobiology School of Immunology and Microbial Sciences King's College London  London UK"},{"name":"National Institute for Health Research Biomedical Research Centre Guy's and St. Thomas' NHS Foundation Trust and Kings College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12085"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(11)60886\u20106"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14\u20100047"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010020\u20100744\u2010z"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7779"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.70074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T03:28:17Z","timestamp":1758770897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.70074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/dmrr.70074"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.70074","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.70074\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v4\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70074\/v4\/decision1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70074"}}