{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:57:42Z","timestamp":1773097062273,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:00:00Z","timestamp":1755216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20OC0065960"],"award-info":[{"award-number":["NNF20OC0065960"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>People with type 1 diabetes are at risk of complications, including impaired bone health. Hyperglycaemia and accumulation of advanced glycation end products (AGEs) are involved in the development of those. Bone measurements such as trabecular bone score (TBS), high\u2010resolution periphery quantitative computed tomography (HR\u2010pQCT), and impact microindentation may detect impaired bone health better than bone mineral density (BMD). Clinical measures reflecting risk factors such as AGE accumulation or prevalence of cardiovascular autonomic neuropathy may also predict low bone quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 111 adults with type 1 diabetes and 37 healthy sex\u2010 and age\u2010matched. Bone health was assessed through DXA with TBS, HR\u2010pQCT and impact microindentation. Accumulation of AGEs was evaluated by skin autofluorescence, and screening for cardiovascular autonomic neuropathy was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean (SD) age of the participants was 42.3 (13.8) years and the median (IQR) BMI was 26.9 [24.5; 30.1] kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Median SkinAGE value was higher in the type 1 diabetes group (2.1 [1.9; 2.7]) than in the control group (1.8 [1.6; 2.3]),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004. In the diabetes group, SkinAGE correlated with femoral neck, total hip BMD, and TBS. SkinAGE showed predictive value for low TBS upon adjustment for age, sex, and BMI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In persons with type 1 diabetes, higher levels of AGE accumulation measured by skin autofluorescence are related to a lower BMD as well as a lower TBS. Along with consideration of age, sex, BMI and other risk factors of osteoporosis, a high skin autofluorescence should increase the suspicion of impaired bone health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70080","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T16:39:24Z","timestamp":1755275964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Skin Autofluorescence May Contribute to Prediction of Low Bone Quality in Type 1 Diabetes\u2014A Clinical Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-454X","authenticated-orcid":false,"given":"Inge Agnete Gerlach","family":"Brandt","sequence":"first","affiliation":[{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"},{"name":"Aalborg University Hospital  Aalborg Denmark"},{"name":"Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Steno Diabetes Center North Denmark  Aalborg Denmark"},{"name":"Aalborg University Hospital  Aalborg Denmark"},{"name":"Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Frost","sequence":"additional","affiliation":[{"name":"University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus Bogh","family":"Juhl","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital  Esbjerg Denmark"},{"name":"Steno Diabetes Center Odense  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torben","family":"Harsl\u00f8f","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444342116"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2016.09.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010017\u20104097\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115457"},{"issue":"1","key":"e_1_2_9_6_1","first-page":"5","article-title":"Increased Risk of Falls, Fall\u2010Related Injuries and Fractures in People With Type 1 and Type 2 Diabetes\u2014A Nationwide Cohort Study","volume":"16","author":"Rasmussen N. 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