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In this review, we present up\u2010to\u2010date knowledge related to the prevention of T1D in youth, involving disease\u2010modifying therapies at different T1D stages. A narrative literature review utilising the PubMed\/MEDLINE database was performed using the keywords \u2018screening\u2019, \u2018prevention\u2019, \u2018Disease\u2010modifying therapy\u2019, and \u2018Diabetes Mellitus, Type 1\u2019 [Mesh] in youth aged 0\u201318\u00a0years. Only teplizumab has been approved by the FDA as the first drug shown to delay the onset of Stage 3 T1D. Other monoclonal antibodies targeting specific immune cells, agents targeting specific cytokines, antigen\u2010specific therapies, and immunomodulant and\/or immunosuppressive agents have been studied alone or in combination to control or delay the progression of beta\u2010cell destruction. In individuals with Stage 3 T1D, several intervention trials have led to a temporary improvement in beta\u2010cell function, but this benefit has consistently been short\u2010lived. Ongoing and future research will be essential to refine patient selection, identify additional therapeutic targets, and optimise the timing and durability of immunotherapy responses.<\/jats:p>","DOI":"10.1002\/dmrr.70101","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:45:32Z","timestamp":1761392732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Are We Ready With Prevention for Type 1 Diabetes?"],"prefix":"10.1002","volume":"41","author":[{"given":"Evelina","family":"Maines","sequence":"first","affiliation":[{"name":"Department of Pediatrics S. 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