{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:48:24Z","timestamp":1784173704892,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RAs) are widely used for type 2 diabetes (T2DM) and obesity, but their potential association with thyroid cancer remains a concern. This study assessed thyroid cancer risk with long\u2010term GLP\u20101RA use in a large real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a propensity score matched cohort study using electronic health records from TriNetX, including 89,646 adults with T2DM who initiated GLP\u20101RA therapy between 2014 and 2020, and demonstrated continued use for at least 1 year. Active comparator controls included users of insulin, metformin, sodium\u2010glucose transporter\u20102 inhibitors, dipeptidyl peptidase\u20104 inhibitors, sulfonylureas, and thiazolidinediones. The primary outcome was the incidence of thyroid cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During a median follow\u2010up of 4.5\u00a0\u00b1\u00a02.3\u00a0years, GLP\u20101RA use was not associated with an increased risk of thyroid cancer compared with any of the other antidiabetic medications. As expected, GLP\u20101RA use was associated with a greater reduction in HbA1c levels, while the negative control outcome remained unaffected. Findings remained consistent across subgroups stratified by sex, age, obesity\u2010status, glycaemic\u2010control, and GLP\u20101RA type and in multiple sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large real\u2010world cohort study, long\u2010term GLP\u20101RA use was not associated with an increased risk of thyroid cancer. These findings provide reassurance for the safety of GLP\u20101RAs and support their continued evidence\u2010based use in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70104","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:46:34Z","timestamp":1762191994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Glucagon\u2010Like Peptide 1 Receptor Agonist Use Is Not Associated With Increased Risk of Thyroid Cancer in Adults With Type 2 Diabetes"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6771-337X","authenticated-orcid":false,"given":"Rena","family":"Pollack","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem 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