{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:44:09Z","timestamp":1792601049763,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T00:00:00Z","timestamp":1765670400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The use of glucagon\u2010like peptide\u20101 (GLP1) analogues has increased due to benefits in glycaemic control, weight loss, and cardiorenal protection. However, concerns persist regarding their potential link to pancreatitis. We assessed this link in high\u2010risk patients with a history of pancreatitis or elevated lipase enzyme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data from a large health maintenance organisation (&gt;\u00a04.5 million insured members) were extracted using the MDClone data\u2010sharing platform, with complete de\u2010identification. We included adults with diabetes who experienced pancreatitis or had elevated lipase (&gt;\u00a01.5 times the upper reference limit), defining an index date for start of follow\u2010up. GLP1 analogues were initiated in a portion of the cohort during the follow\u2010up period. Patients who had used GLP1 analogues prior to or within 1\u00a0month of the index date were excluded. The primary outcome was recurrent pancreatitis. Survival and multivariate analyses, including time\u2010varying models, were performed to assess the impact of GLP1 analogues on recurrent pancreatitis risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort included 46,186 patients (10,933 for pancreatitis, and 35,253 for elevated lipase, 55% men, median age 70.9\u00a0years). GLP1 analogue use was an independent risk factor for recurrent pancreatitis in a time\u2010varying analysis (HR 1.252, 95% CI 1.178\u20131.332). This remained significant after adjusting for factors like gender, alcohol use, and medications associated with pancreatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An increased risk of recurrent pancreatitis was observed in high\u2010risk patients receiving GLP1 analogue therapy. These findings align with pharmacovigilance data and support caution when prescribing GLP1 analogues in this population. Prospective studies are warranted to further evaluate this association.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70116","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T06:56:59Z","timestamp":1765781819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Glucagon\u2010Like Peptide\u20101 Analogues and the Risk of Recurrent Pancreatitis in Diabetic Patients With History of Pancreatitis or Elevated Lipase: Retrospective Cohort Analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5124-0748","authenticated-orcid":false,"given":"Bronya","family":"Calvarysky","sequence":"first","affiliation":[{"name":"Pharmacy Rabin Medical Center Beilinson Hospital  Petah Tikva Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem 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