{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:21:06Z","timestamp":1790659266413,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010800","name":"Hadassah Medical Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2139\/21"],"award-info":[{"award-number":["2139\/21"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is a growing public health concern that contributes to liver and cardiovascular complications. The prevalence of MASLD in women increases sharply around age 50\u00a0years, but the relationship between an earlier age at natural menopause and MASLD is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using the TriNetX global federated network, we identified women with earlier menopause (&lt; 50\u00a0years). The control cohort consisted of similarly aged pre\u2010menopausal women. Cases of premature (&lt; 40\u00a0years) or surgical menopause, non\u2010MASLD causes of steatotic liver disease (SLD), or sex\u2010hormone therapy were excluded. Propensity\u2010score matching adjusted for baseline characteristics and metabolic risk factors, resulting in two matched cohorts of 20,979 women (total\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a041,958) in the final analysis. Outcomes included new diagnoses of MASLD (metabolic dysfunction\u2010associated steatohepatitis) and the MASLD metabolic factors: pre\u2010diabetes\/diabetes, hypertension, dyslipidaemia, and overweight\/obesity over 5 years of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Earlier menopause was associated with an increased risk of developing MASLD (HR 1.322, 95% CI 1.170\u20131.492), new\u2010onset dyslipidaemia (1.083; 1.045\u20131.122) and pre\u2010diabetes (1.130; 1.060\u20131.205). Findings were consistent across stratified analyses by pre\u2010existing metabolic risk factors (HR 95% CI for MASLD with pre\u2010existing dysglycaemia 1.370, 1.042\u20131.800; dyslipidaemia 1.340, 1.053\u20131.705; hypertension 1.230, 0.998\u20131.516; overweight 1.280, 1.086\u20131.510).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Risk of MASLD is increased following menopause before age 50. Further studies should assess the incorporation of menopause timing into female\u2010specific cardiometabolic risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70121","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T13:19:48Z","timestamp":1768051188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Earlier Menopause and Risk of Metabolic Dysfunction\u2010Associated Steatotic Liver Disease: A Global Cohort Study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-5800","authenticated-orcid":false,"given":"Joshua","family":"Stokar","sequence":"first","affiliation":[{"name":"Department of Endocrinology Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0807-4963","authenticated-orcid":false,"given":"Rivka","family":"Dresner\u2010Pollak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hadassah Medical Center  Jerusalem Israel"},{"name":"Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem 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