{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:18:05Z","timestamp":1782386285218,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004699","name":"Chung Shan Medical University Hospital","doi-asserted-by":"publisher","award":["CSH\u20102020\u2010C\u2010001"],"award-info":[{"award-number":["CSH\u20102020\u2010C\u2010001"]}],"id":[{"id":"10.13039\/501100004699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type 2 diabetes (T2D) and chronic kidney disease (CKD) increase the risk of ischaemic and haemorrhagic strokes. However, the effect of sodium\u2010glucose cotransporter 2 inhibitors (SGLT2i) on reducing the risk of ischaemic and haemorrhagic strokes in patients with T2D and CKD remains unclear. Thus, this study was conducted to explore the role of SGLT2i in the prevention of ischaemic and haemorrhagic strokes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, Cox regression analysis was employed to examine the hazard ratio (HR) between users and nonusers of SGLT2i on incident ischaemic and haemorrhagic strokes following 1:1 propensity score matching. The Kaplan\u2013Meier method was used to determine the risk of study outcome over time between users and nonusers of SGLT2i. Finally, a sensitivity analysis of the HR was performed between users and nonusers of SGLT2i on incident ischaemic and haemorrhagic strokes after 1:2 sex and age matching.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 1:1 propensity score matching of patients by age, sex, T2D duration, and comorbidities, 107,819 users of SGLT2i and 107,819 nonusers were enrolled for analysis. SGLT2i therapy was associated with significantly reduced incidence of ischaemic and haemorrhagic strokes (HR 0.86, [95% CI, 0.81\u20130.90]; HR 0.80, [95% CI, 0.74\u20130.87]). Furthermore, the HR was even more significant in the sensitivity test for incident ischaemic and haemorrhagic strokes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SGLT2i reduced the risk of incident ischaemic and haemorrhagic strokes among patients with T2D and CKD. The protective profile of the SGLT2i against incident ischaemic and haemorrhagic strokes makes it a clinical option for those with T2D with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70122","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T10:21:22Z","timestamp":1768386082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of New\u2010Onset Ischaemic and Haemorrhagic Stroke in Patients With Type 2 Diabetes With Chronic Kidney Disease on SGLT\u20102 Inhibitor Users: A Population\u2010Based Cohort Study"],"prefix":"10.1002","volume":"42","author":[{"given":"Ya\u2010Hui","family":"Lin","sequence":"first","affiliation":[{"name":"College of Nursing Central Taiwan University of Science and Technology  Taichung Taiwan (ROC)"},{"name":"Department of Pharmacy Taichung Armed Forces General Hospital  Taichung Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Kun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tre\u2010Service General Hospital  Taipei Taiwan (ROC)"},{"name":"School of Pharmacy National Defense Medical University  Taipei Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6645-3657","authenticated-orcid":false,"given":"Pei\u2010Lun","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University Hospital  Taichung Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung Shan Medical University Hospital  Taichung Taiwan (ROC)"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-5497","authenticated-orcid":false,"given":"Gwo\u2010Ping","family":"Jong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chung Shan Medical University Hospital  Taichung Taiwan (ROC)"},{"name":"Institute of Medicine Chung Shan Medical University  Taichung Taiwan (ROC)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211065917"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102106\u20104732"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.1505"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.6515\/ACS.202109_37(5).20210324A"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.23736\/s2724\u20105683.22.05891\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvac016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003133\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.118.011139"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213\u20108587(24)00102\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.6515\/ACS.202011_36(6).20200511A"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1811744"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.069568"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13295"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201094945\u20104"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.6515\/ACS.202501_41(1).20240916B"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm.2018.02.907"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010020\u201001197\u2010z"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvad078"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2409183"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.966708"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2024.01.013"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13195786"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.120.031623"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1504720"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1611925"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1812389"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2004967"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.09380822"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2204233"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2409183"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.777861"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.70122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.70122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.70122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:44:46Z","timestamp":1773128686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.70122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/dmrr.70122"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.70122","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/DMRR.70122\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70122\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/DMRR.70122\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70122"}}