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Pooled relative risks (RRs) and 95% confidence intervals (CIs) for each outcome were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In 17 RCTs comprising 36,415 patients, GLP\u20101 RAs was associated with a significantly reduced risk of colon cancer (RR, 0.34; 95% CI, 0.17\u20130.68;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.0%), and showed a neutral effect on the risk of colorectal carcinoma, rectal, and intestinal cancer, with RRs of 1.13 (95% CI, 0.92\u20131.39;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.0%), 3.64 (95% CI, 0.76\u201317.40;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.0%), and 0.76 (95% CI, 0.31\u20131.84;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a023.3%), respectively. In the network meta\u2010analysis and subgroup analysis, a potential association was observed between albiglutide and subcutaneous semaglutide and a lower incidence of colon cancer among adults treated for a longer duration and with lower baseline HbA1c levels, regardless of baseline body mass index, age, or type of control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RAs may be associated with a lower risk of colon cancer in adults with type 2 diabetes mellitus, warranting further validation in trials among high\u2010risk populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The study protocol was pre\u2010registered and published on PROSPERO (CRD: 42024548010;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/#recordDetails\">https:\/\/www.crd.york.ac.uk\/prospero\/#recordDetails<\/jats:ext-link>\n                      )\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70134","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T08:55:57Z","timestamp":1770800157000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association Between GLP\u20101 Receptor Agonists and the Risk of Colon Cancer in Adults With Type 2 Diabetes or Obesity: A Systematic Review and Network Meta\u2010Analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-669X","authenticated-orcid":false,"given":"Man","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University, and Metabolic Vascular Disease Key Laboratory of Sichuan Province, and Sichuan\u2010Chongqing Joint Key Laboratory of Metabolic Vascular Diseases  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University, and Metabolic Vascular Disease Key Laboratory of Sichuan Province, and Sichuan\u2010Chongqing Joint Key Laboratory of Metabolic Vascular Diseases  Luzhou China"},{"name":"Department of Intensive Care Unit The Affiliated Hospital of Southwest Medical University  Luzhou China"},{"name":"Department of Intensive Care Unit Wangcang People's Hospital  Guangyuan 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