{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:40:52Z","timestamp":1783021252826,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20364"],"award-info":[{"award-number":["U22A20364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870364"],"award-info":[{"award-number":["81870364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Obesity has been linked to elevated intraocular pressure (IOP); however, the metabolic pathways connecting body mass index (BMI) to IOP remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a prospective cohort study within the Jidong Eye Cohort (2022\u20132023, Tangshan, China) involving 2400 adults aged 18\u201365\u00a0years without diabetes. BMI was measured continuously, with obesity defined according to the Chinese national standard Criteria of Weight for Adults (WS\/T 428\u20142013) (BMI\u00a0\u2265\u00a028\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), and IOP assessed bilaterally by standardised tonometry. Longitudinal associations between BMI and IOP were evaluated using linear mixed\u2010effects models, and mediation through the triglyceride\u2010glucose (TyG) index and hypertension was quantified by structural equation modelling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, obesity was associated with higher IOP than non\u2010obesity (right: 16.37 vs. 15.78\u00a0mmHg; left: 16.65 vs. 16.05\u00a0mmHg;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Higher BMI predicted increased IOP over time after adjusting for demographic, behavioural, and metabolic factors. Mediation analysis indicated that 43.4% of the total effect was indirect, mainly via TyG (0.0182), hypertension (0.0079), and their sequential path (0.0014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TyG index explained a larger share of the mediated effect than hypertension, while the remaining direct effect suggested additional mechanisms. These findings support incorporating metabolic profiling into early ocular risk assessment for individuals with elevated BMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70142","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:10:03Z","timestamp":1773317403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Body Mass Index and Intraocular Pressure in a Chinese Adult Population"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4731-0108","authenticated-orcid":false,"given":"Yuehao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Experiment &amp; Research, South China Hospital, Medical School Shenzhen University  Shenzhen China"},{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering Shenzhen University Medical School  Shenzhen China"},{"name":"Department of Pediatrics The Third People\u2019s Hospital of Longgang District Shenzhen  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-8834","authenticated-orcid":false,"given":"Xue","family":"Fan","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-1634","authenticated-orcid":false,"given":"Weifang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Taizhou Central Hospital (Taizhou University Hospital)  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangyang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine Taizhou University  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingdong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofu","family":"Chen","sequence":"additional","affiliation":[{"name":"Taizhou Central 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