{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:16:38Z","timestamp":1783012598894,"version":"3.54.6"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The global rise of obesity has accelerated the onset of type\u20102 diabetes mellitus (T2DM) also among youth. Early detection of impaired \u03b2\u2010cell function in at\u2010risk populations is crucial for prevention; however, reference standards for children and adolescents remain scarce. We aimed to establish population\u2010based percentile distributions specific to developmental stage and weight status for multiple markers of \u03b2\u2010cell function in Chilean youth, thereby addressing this critical gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional study in 988 children and adolescents aged 6\u201317\u00a0years. Anthropometric measurements included weight, height, and waist circumference; weight status was classified using WHO 2007 standards. Participants were stratified into three developmental groups: Tanner 1\u20132 (G1), Tanner 3\u20135 (G2), and adolescents \u2265\u00a016\u00a0years (G3). Fasting glucose and insulin were measured; insulin sensitivity and \u03b2\u2010cell function were estimated using HOMA. Disposition index (DI) was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>G2 participants exhibited higher insulin, HOMA\u2010IR, and HOMA\u2010\u03b2 levels, alongside lower HOMA\u2010S levels compared to G1 and G3. Across all developmental groups, \u03b2\u2010cell function varied by weight status: normal\u2010weight individuals displayed more favourable insulin profiles than those with overweight or obesity. DI declined significantly with excess weight in G3, although values remained below 1.0 across groups. Fasting glucose was consistently within the normal range, independent of weight status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that differences in \u03b2\u2010cell function may be present even in the context of normal fasting glucose, indicating that glycaemia alone may not fully capture early variations in glucose\u2013insulin dynamics. Since pubertal stage and adiposity significantly influenced these results, incorporating development\u2010 and weight\u2010specific considerations may improve the interpretation of metabolic markers during growth. These findings support the need for more nuanced approaches to characterise metabolic variability in youth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70172","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:13:08Z","timestamp":1776849188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compensated But Failing: Early \u03b2\u2010Cell Dysfunction Under\u00a0Normoglycemia in Children and Adolescents With\u00a0Overweight and Obesity"],"prefix":"10.1002","volume":"42","author":[{"given":"Paulina","family":"Correa\u2010Burrows","sequence":"first","affiliation":[{"name":"Institute of Nutrition &amp; Food Technology Universidad de Chile  Santiago Chile"},{"name":"Geroscience Center for Healthy Longevity and Public Policy Universidad de Chile  Santiago 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