{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:16:40Z","timestamp":1783012600371,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To determine whether recovery of fasting C\u2010peptide (\u0394FCP) reduces deterioration in sudomotor small\u2010fibre function, whether a threshold exists, and whether associations are complication\u2010specific.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective real\u2010world cohort of 288 hospitalised adults with diabetes with repeated fasting C\u2010peptide and Sudoscan electrochemical skin conductance (ESC). Deterioration in sudomotor small\u2010fibre function was defined as worsening foot ESC. Large\u2010fibre neuropathy (LFN) and diabetic kidney disease (DKD) progression were assessed by nerve conduction and kidney outcomes. Cox models, restricted cubic splines, maximally selected rank statistics, and subgroup\/landmark\/sensitivity analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median 2.2\u00a0years, higher \u0394FCP was independently associated with lower risk of deterioration in sudomotor small\u2010fibre function, but not with LFN or DKD progression. Highest versus lowest \u0394FCP tertile: adjusted HR 0.31 (95% CI 0.14\u20130.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). An optimal \u0394FCP cutoff of 126.8\u00a0pmol\/L was identified; \u0394FCP \u2265\u00a0126.8\u00a0pmol\/L was associated with a 66% lower risk of sudomotor deterioration (HR 0.34, 95% CI 0.17\u20130.69;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), remaining robust in landmark and sensitivity analyses. Baseline C\u2010peptide mediated little of the association.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Endogenous fasting C\u2010peptide recovery is linked to a clinically meaningful, threshold\u2010dependent reduction in the progression of sudomotor small\u2010fibre dysfunction, supporting\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2010cell preservation\/recovery as targets in early diabetic neuropathy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70173","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:12:56Z","timestamp":1777378376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endogenous Recovery of Fasting C\u2010Peptide Decreases Progression of Sudomotor Small\u2010Fibre Dysfunction in Adults With Diabetes: A Real\u2010World Cohort Study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4760-4699","authenticated-orcid":false,"given":"Qingyun","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Endocrinology Beijing Hospital National Center of Gerontology  Beijing China"},{"name":"Peking Union Medical College Graduate School Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjian","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-1798","authenticated-orcid":false,"given":"Lixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital National Center of Gerontology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-1439","authenticated-orcid":false,"given":"Qi","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Hospital National Center of Gerontology  Beijing China"},{"name":"Peking Union Medical College Graduate School Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12159"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14\u20101952"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.15469"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20105448.2010.00729.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116950"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.31.1_supplement.715.2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23\u20101553\u2010P"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8883736"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.10.3077"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.536"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2020.101322"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.81714"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15\u20102068"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2019.12.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010019\u20101212\u20108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296821996434"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u2010S002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.243"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)32064\u20105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(19)30081\u20106"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2013.0129"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00199"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2359"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5325.563"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00\u20100183com"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.536"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.137"}],"container-title":["Diabetes\/Metabolism 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