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This review explains the central hub role of microRNAs in obesity\u2010related chronic low\u2010grade inflammation, achieved through their precise regulation of macrophage polarisation, inflammatory signalling pathways, and adipokine secretion. Importantly, this relationship is bidirectional\u2014while miRNAs regulate inflammatory cascades, the inflammatory environment itself can alter miRNA expression, forming complex feedback loops. Circulating miRNAs, due to their stability (conferred by encapsulation in exosomes or binding to proteins), tissue specificity, and strong correlation with pathological processes, show great potential as promising non\u2010invasive biomarkers for metabolic inflammation, useful for assessing its activity and complication risk. Furthermore, miRNA\u2010based intervention strategies have demonstrated significant metabolic improvements in animal models. 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