{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:28:37Z","timestamp":1792506517620,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The use of pharmacotherapies with weight loss properties for the management of obesity and chronic disease are now routinely prescribed. We investigated the evidence from randomised\u2010controlled trials for the effects on lean body mass of glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RA) and sodium\u2010glucose co\u2010transporter\u20102 inhibitors (SGLT2i) in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>PubMed, MEDLINE, the Cochrane Library and CINAHL were searched from inception to October 2022. The primary outcome was change in body composition focused on measures of lean body mass (LBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010six studies in population groups with obesity (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a08), type 2 diabetes mellitus (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020), type 1 diabetes mellitus (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05) and polycystic ovary syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03) receiving a GLP\u20101RA or SGLT2i therapy versus placebo or active comparator satisfied our inclusion criteria, including 21 for GLP\u20101RA and 15 for SGLT2i. Meta\u2010analysis showed an overall loss of LBM in the direction of the intervention groups prescribed GLP\u20101RA (MD: \u22121.51\u00a0kg [95% CI: \u22122.00 to \u22121.01]) and SGLT2i (MD: \u22121.04\u00a0kg [95% CI: \u22121.45 to \u22120.64]) with sub\u2010group analysis showing largely consistent results when stratified by type of body composition outcome, type of body composition measurement technique and disease status. Results were not modified by sex. Further meta\u2010analysis found that lean mass accounted for 28% (95% CI: 22%\u201334%) of overall weight loss induced by GLP\u20101RA and SGLT2i.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101RA and SGLT2i are associated with a loss of LBM that appears congruent with overall weight loss. Monitoring of body composition and provision of combined therapy to preserve lean mass during weight loss should be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70194","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T18:14:52Z","timestamp":1781892892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effects of Glucagon\u2010Like Peptide\u20101 Receptor Agonists and Sodium\u2010Glucose Co\u2010Transporter\u20102 Inhibitors on Lean Body Mass in Humans: A Systematic Review and Meta\u2010Analysis of Randomised Controlled Trials"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-1646","authenticated-orcid":false,"given":"Rishi","family":"Jobanputra","sequence":"first","affiliation":[{"name":"Diabetes Research Centre University of Leicester  Leicester UK"},{"name":"National Institute for Health Research 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Health Research (NIHR) Leicester Biomedical Research Centre  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-1230","authenticated-orcid":false,"given":"Abdullah","family":"Almaqhawi","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine King Faisal University  Al Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Webb","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester  Leicester UK"},{"name":"National Institute for Health Research (NIHR) Leicester Biomedical Research Centre  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Diabetes Research Centre University of Leicester  Leicester UK"},{"name":"National Institute for Health Research (NIHR) Leicester Biomedical 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