{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:26:52Z","timestamp":1791815212748,"version":"4.3.4"},"reference-count":217,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Metabolic disorders such as obesity, type 2 diabetes mellitus, and fatty liver disease are associated with a disruption in the coordinated regulation of nutrient sensing, energy metabolism, and cellular homoeostasis. Increasing evidence indicates that sirtuins, a family of NAD\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent enzymes, play a central role in integrating metabolic and stress\u2010responsive pathways. By coupling the cellular redox state to transcriptional and post\u2010translational regulation, sirtuins coordinate key processes such as glucose and lipid metabolism, mitochondrial function, and inflammatory signalling. Sirtuins are functionally specialised according to their subcellular localisation. Nuclear sirtuins (SIRT1, SIRT6, and SIRT7) regulate transcriptional programs controlling metabolism and inflammation, whereas mitochondrial sirtuins (SIRT3, SIRT4, and SIRT5) directly modulate metabolic enzyme activity and redox homoeostasis. SIRT2 links cytosolic metabolic signalling to cytoskeletal dynamics and cell cycle regulation. Importantly, the activity of all sirtuins is tightly dependent on NAD\n                    <jats:sup>+<\/jats:sup>\n                    availability, positioning NAD\n                    <jats:sup>+<\/jats:sup>\n                    metabolism as a central regulator of the sirtuin network. In this review, we provide a systems\u2010level perspective on sirtuin biology, highlighting how NAD\n                    <jats:sup>+<\/jats:sup>\n                    metabolism, subcellular compartmentalisation, and specific functions converge to form an integrated regulatory network governing metabolic homoeostasis. We further discuss how disruption of this network contributes to the pathogenesis of metabolic disorders through impaired metabolic flexibility, mitochondrial dysfunction, and chronic inflammation. Overall, this network\u2010based framework provides a unified view of sirtuin function in metabolic regulation and helps to explain the complexity and tissue\u2010specific heterogeneity of metabolic diseases.\n                  <\/jats:p>","DOI":"10.1002\/dmrr.70201","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:18:55Z","timestamp":1783984735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Sirtuin Network: Linking NAD\n                    <sup>+<\/sup>\n                    Metabolism, Mitochondrial Function, and Metabolic Homoeostasis"],"prefix":"10.1002","volume":"42","author":[{"given":"Ewa","family":"Szcz\u0119sny\u2010Ma\u0142ysiak","sequence":"first","affiliation":[{"name":"Jagiellonian Centre for Experimental Therapeutics Jagiellonian University  Krakow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Schiavoni","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Rotondo","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"},{"name":"IRCCS San Raffaele Roma  Cassino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Donati","family":"Zeppa","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Vignini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Polytechnic University of Marche  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Moriconi","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"},{"name":"Internal Medicine Hospital Isola Tiberina\u2014Gemelli Isola  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Cecati","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Armani","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"},{"name":"Laboratory of Cardiovascular Endocrinology IRCCS San Raffaele  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Gorini","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"},{"name":"Laboratory of Cardiovascular Endocrinology IRCCS San Raffaele  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0722-7163","authenticated-orcid":false,"given":"Massimiliano","family":"Caprio","sequence":"additional","affiliation":[{"name":"Department for the Promotion of Human Science and Quality of Life San Raffaele Roma University  Rome Italy"},{"name":"Laboratory of Cardiovascular Endocrinology IRCCS San Raffaele  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010022\u201000746\u20108"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010323071"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041158"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12389"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath\u20102019\u2010205910"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020786"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20108587(20)30381\u20108"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab199"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1592683"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/35001622"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.03.004"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3293"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070140"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30377"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.06.001"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.05.022"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.11.013"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.70069"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704329104"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.107037"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom8030044"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.06.009"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv167"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11043"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12235"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.08.018"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz2590"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08778"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.06.008"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741\u2010023\u201010295\u20105"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11872"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01006"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.116"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad155"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI187020"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097\u20102765(03)00038\u20108"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12020376"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202113943"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp\u20102024\u20100400"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.10.027"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114019"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010023\u201001280\u2010z"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119082"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.02.004"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091173"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1410479"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11111594"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.23209"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2025.09.017"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15091281"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000313\u2010x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099196"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.09.005"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2014.04.002"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.12.041"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.06.009"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.476903"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13010048"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12\u20101650"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.057"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.046"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44324\u2010025\u201000067\u20100"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03354"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.006"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201024864\u20101"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2025.00259"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.027"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.11.016"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.813272"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu156"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00474"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1207861"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.014"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1706945114"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02583"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474\u20109726.2007.00335.x"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.02.007"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601633"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2013.10.006"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.07.003"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e08\u201006\u20100647"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366\u2010019\u20100436\u20107"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414670200"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.04.008"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181705"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18\u20101103"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051126"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.006"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2020.108260"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800241200"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16\u20101225"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.06.069"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.07.023"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.052"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201017\u20100033"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13567"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201035219\u2010z"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014821"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069236\u2010z"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.05.025"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2010.07.003"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.02.026"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010021\u201000498\u20101"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.003"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69413"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803790105"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201404118"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.11.015"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.12.013"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.002"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.1040"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.124164"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00087\u201013"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00293"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.10.017"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122297"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1009778"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911954116"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545\u2010010\u20109061\u20102"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi100742w"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0390833"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705070104"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2008.02.004"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805711200"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.08.001"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.17420111"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8121584"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.111765"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.12.001"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00748"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2021.1956976"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12081079"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010025\u201001142\u20108"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45887"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes24013"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909917116"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab006"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20103054"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2020.108377"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129192"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.977485"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.05.005"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.746151"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033800\u20100"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2023.0011"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009\u20101013"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE\u201014\u20100527"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.05.006"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.025"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.10.059"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1068986"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.202390"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21020372"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.021"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.05.012"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010021\u201000664\u20101"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474\u20109726.2009.00544.x"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01607"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087759\u2010x"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010014\u20100465\u2010x"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2016.06.001"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00449"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010025\u201003613\u20108"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010015\u20101859\u20104"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2021.03.005"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113506"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14050983"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201038843\u2010x"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094785"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu18081239"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201007575\u20103"},{"issue":"2","key":"e_1_2_12_176_1","article-title":"Dysregulation of HO\u20101\u2010SIRT1 Axis Is Associated With AngII\u2010Induced Adipocyte Dysfunction","volume":"8","author":"Lakhani H. V.","year":"2024","journal-title":"Journal of Clinical and Medical Sciences"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040031"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07\u20101795"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.08.014"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2011.01.008"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00705\u201008"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00417.2009"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061035098"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07349"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702509104"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607215200"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00122.2017"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16\u20101446"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.9.3514\u20103526.2006"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01667"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1411026111"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.168039"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010017\u20104542\u20106"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099049"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111308108"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.55330"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1291501"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20100791"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.09.037"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.006"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2013.04.001"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171469"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7543973"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.435107"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24938"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.733696"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101068"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad102"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01173"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2017.1320004"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.355206"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.07.019"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169118"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00027.2014"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.01.009"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccs3.70031"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR\u2010D\u201023\u201002063"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7178"}],"container-title":["Diabetes\/Metabolism Research and Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.70201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dmrr.70201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dmrr.70201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:48:01Z","timestamp":1785170881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dmrr.70201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":217,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dmrr.70201"],"URL":"https:\/\/doi.org\/10.1002\/dmrr.70201","archive":["Portico"],"relation":{},"ISSN":["1520-7552","1520-7560"],"issn-type":[{"value":"1520-7552","type":"print"},{"value":"1520-7560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70201"}}