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Randomized control trials (RCTs) and cohort studies comparing SGLT\u20102i, GLP\u20101RA and DPP\u20104i in diabetes were selected. We performed a network meta\u2010analysis to compare the three drugs indirectly. Results were reported as risk ration (RR) with corresponding 95% confidence interval (CI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>4 RCTs and 21 cohort studies involving 2,171,267 patients were included. Compared with GLP\u20101RA [RR with 95% CI: 0.86(0.79, 0.95), RR with 95% CI: 0.87(0.78, 0.97)] and DPP\u20104i[RR with 95% CI: 0.80(0.74, 0.87), RR with 95% CI: 0.81(0.74, 0.88)], SGLT\u20102i significantly reduced the risk of AF and new\u2010onset AF. While there were no significant difference in the risk of AF recurrence among SGLT\u20102i, GLP\u20101RA, and DPP\u20104i[RR with 95% CI: 0.87(0.68, 1.12), RR with 95% CI: 0.80(0.61, 1.05), RR with 95% CI: 0.92(0.63, 1.33)]. There were also no significant difference in the risk of AF and new\u2010onset AF between GLP\u20101RA and DPP\u20104i[RR with 95% CI: 0.93(0.84, 1.03), RR with 95% CI: 0.93(0.83, 1.04)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The management of T2DM involves the prevention of subsequent cardiovascular complications. The results of this network meta\u2010analysis indicate that SGLT2i is associated with a lower risk of AF in T2DM patients compared to GLP\u20101RA and DPP\u20104i. Sensitivity analysis further confirms that SGLT\u20102i significantly reduces the risk of AF recurrence statistically. These finding suggests that SGLT\u20102i should be considered as a preferred antidiabetic regimen for patients with T2DM at high risk of AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70202","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:10:46Z","timestamp":1784139046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network and Pairwise Meta\u2010Analysis of the Association Between Novel Hypoglycemic Agents and Atrial Fibrillation Risk in Patients With Type 2 Diabetes Mellitus"],"prefix":"10.1002","volume":"42","author":[{"given":"Xuejiao","family":"Ye","sequence":"first","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5500-3706","authenticated-orcid":false,"given":"Qian","family":"Wu","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linye","family":"Hou","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzheng","family":"Hou","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1561-7217","authenticated-orcid":false,"given":"Yingtian","family":"Yang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyan","family":"Yang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Huang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-5834","authenticated-orcid":false,"given":"Shihan","family":"Wang","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Guang\u2019Anmen Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"IDF Diabetes Atlas","author":"Magliano D. 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