{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:55:36Z","timestamp":1790571336398,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study included 26 men with normal weight and 78 men with obesity. Body composition\u00a0was\u00a0measured using dual\u2010emission X\u2010ray absorptiometry. Subcutaneous fat, visceral fat and fat content in the liver\u00a0and\u00a0pancreas were determined by magnetic resonance. Serum sclerostin, irisin and leptin were detected using the Elisa\u00a0assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with men with normal weight, serum sclerostin, irisin and leptin levels as well as whole\u2010body and spinal\u00a0bone mineral density were increased, whereas pelvic bone mineral density was not different in men with obesity.\u00a0Partial analysis showed that in men with obesity, serum sclerostin was positively correlated with bone mineral density but not with body composition; serum irisin was positively correlated with fat mass percent, negatively correlated with muscle mass percent, but not with bone mineral density; serum leptin was positively correlated with fat mass, while negatively associated with muscle mass and bone mineral density. Furthermore, body weight showed beneficial effects on whole\u2010body and spinal bone, whereas central fat distribution exerted adverse effects on pelvic bone. Stepwise linear regression revealed\u00a0that serum sclerostin and whole\u2010body muscle mass were independent predictors of bone mineral density in the over\u2010all cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum sclerostin, irisin and leptin show distinct correlations with body composition and bone mineral density in men with obesity, which may partly reflect the complex effects of obesity on bone metabolism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70208","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T05:53:08Z","timestamp":1785995588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Bone\u2010, Muscle\u2010 and Fat\u2010 Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"42","author":[{"given":"Xiang","family":"Chen","sequence":"first","affiliation":[{"name":"Laboratory of Endocrinology and Metabolism Division of Endocrinology and Metabolism West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Science and Technology West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Science and Technology West China Hospital Sichuan University  Chengdu Sichuan 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