{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:32:01Z","timestamp":1791243121224,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003286","name":"Kuwait Foundation for the Advancement of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study examined changes in body composition and bone mineral density (BMD) over 12\u00a0months in people with obesity and type 1 diabetes (T1D) treated with a GLP\u20101 receptor agonist alone (GLP\u20101RA) or a dual glucose\u2010dependent insulinotropic polypeptide (GIP\/GLP\u20101RA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This real\u2010world observational study included 70 people with obesity and T1D treated with GLP\u20101RA alone or dual GIP\/GLP\u20101RA. Dual\u2010energy X\u2010ray absorptiometry (DEXA) was used to quantify regional and total fat mass, lean mass, bone mineral content (BMC) and BMD at baseline and after 12\u00a0months of treatment. Overall changes were quantified, and changes stratified by percentage weight loss using repeated measures analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over 12\u00a0months body weight (\u22126.33%; 95% CI: \u22127.92, \u22124.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), HbA1c (\u22120.48%; 95% CI: \u22120.74, \u22120.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), total tissue fat (\u22121.42%; 95% CI: \u22122.47, \u22120.36;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009), fat mass (\u22125.90%; 95% CI: \u221210.50, \u22121.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), and lean mass (\u22121.75%; 95% CI: \u22123.50, \u22120.48;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005) decreased, while total BMC and BMD remained unchanged. Total lean mass loss was associated with body weight loss (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In people with obesity and T1D, 12\u2010month GLP\u20101RA alone or dual GIP\/GLP\u20101RA therapy resulted in clinically meaningful weight loss, improved glycaemic control, preferential fat mass reduction, modest lean mass loss, and preservation of total BMD. People achieving &gt;\u00a010% weight loss derived the greatest metabolic benefit without compromising bone health, although the loss of lean mass was greater.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dmrr.70213","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T17:35:55Z","timestamp":1785951355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Weight Loss\u2010Dependent Changes in Body Composition and Bone Health in People With Obesity and Type 1 Diabetes Treated With Liraglutide, Semaglutide, or Tirzepatide"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-4369","authenticated-orcid":false,"given":"Ebaa","family":"Al Ozairi","sequence":"first","affiliation":[{"name":"DAFNE Unit Clinical Care Research and Trials Unit Dasman Diabetes Institute  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-0221","authenticated-orcid":false,"given":"Mohammad","family":"Irshad","sequence":"additional","affiliation":[{"name":"DAFNE Unit Clinical Care Research and Trials Unit Dasman Diabetes Institute  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumana","family":"Alkandri","sequence":"additional","affiliation":[{"name":"DAFNE Unit Clinical Care Research and Trials Unit Dasman Diabetes Institute  Kuwait City Kuwait"},{"name":"Al\u2010Amiri Hospital Ministry of Health  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6166-4626","authenticated-orcid":false,"given":"Anant","family":"Mashankar","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Center Dasman Diabetes Institute  Kuwait City Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8969-9636","authenticated-orcid":false,"given":"Stuart R.","family":"Gray","sequence":"additional","affiliation":[{"name":"School of Cardiovascular and Metabolic Health University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5521-5445","authenticated-orcid":false,"given":"Carel W.","family":"le Roux","sequence":"additional","affiliation":[{"name":"Diabetes Complications Research Centre University College Dublin  Dublin UK"},{"name":"School of Medicine Ulster University  Coleraine 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