{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:20:59Z","timestamp":1767676859647},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,10]],"date-time":"2007-08-10T00:00:00Z","timestamp":1186704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The production of oxidative stress as a result of postprandial hyperglycaemia is now recognized as an important contributing factor in the development of diabetes complications. The objective of this study was to examine the effects of pramlintide on plasma concentrations of glucose and several markers of oxidative stress in patients with type 2 diabetes following a standardized meal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, single\u2010blind, placebo\u2010controlled, crossover study conducted at two clinical research centres in the United States. A total of 19 subjects (9 men and 10 women) with type 2 diabetes using mealtime insulin participated in the study. Pramlintide (120 \u00b5g), or placebo, and rapid\u2010acting mealtime insulin were administered prior to a standardized meal on two separate study days. Plasma concentrations of glucose, nitrotyrosine (NT), oxidized\u2010LDL cholesterol (OxLDL\u2010C), and total radical trapping parameter (TRAP) were assessed during the 4\u2010h postprandial period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to placebo, pramlintide treatment reduced postprandial excursions of glucose, NT, and OxLDL\u2010C and protected TRAP from consumption. Correlation analysis revealed positive associations between placebo\u2010corrected glucose incremental AUC<jats:sub>0\u20134h<\/jats:sub> and both NT and OxLDL\u2010C and a negative association between placebo\u2010corrected glucose incremental AUC<jats:sub>0\u20134h<\/jats:sub> and TRAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The reduction in postprandial glucose excursions achieved with addition of pramlintide to rapid\u2010acting insulin in type 2 diabetes was associated with a reduction in postprandial markers of oxidative stress. 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