{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:03:37Z","timestamp":1791187417133,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,10,5]],"date-time":"2007-10-05T00:00:00Z","timestamp":1191542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diabetes Metabolism Res"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the clinical utility of pancreatic scintigraphy with 99mTc\u2010interleukin\u20102 to identify Type 1 diabetic patients with pancreatic inflammation at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>99mTc\u2010interleukin\u20102 scintigraphy was performed on 42 newly diagnosed Type 1 diabetic patients, before and after 1 year of treatment with nicotinamide (25 or 50 mg\/kg\/day) in addition to intensive insulin therapy. Metabolic status was monitored every 3 months for 1 year. Sixteen normal subjects were studied as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant pancreatic accumulation of 99mTc\u2010interleukin\u20102 was found in 31% of the patients at the time of diagnosis. Patients positive or negative for pancreatic accumulation of interleukin\u20102 scintigraphy did not show any difference in metabolic or immunologic parameters at diagnosis. Positive patients, however, showed higher C\u2010peptide values at 3 months and lower insulin requirement at 1 year, compared to negative patients (insulin requirement (<jats:italic>IR<\/jats:italic>): 0.33 \u00b1 0.11 <jats:italic>vs<\/jats:italic> 0.67 \u00b1 0.24 IU\/kg\/day, positive <jats:italic>vs<\/jats:italic> negative patients; <jats:italic>p<\/jats:italic> = 0.0001); patients positive to IL2 scintigraphy treated with nicotinamide at 25 mg\/kg were the only group showing a significant reduction in IR 1 year after diagnosis (<jats:italic>IRt<\/jats:italic><jats:sub>0<\/jats:sub>: 0.53 \u00b1 0.30 <jats:italic>vs<\/jats:italic> <jats:italic>IRt<\/jats:italic><jats:sub>12<\/jats:sub>: 0.28 \u00b1 0.07 IU\/kg\/day; <jats:italic>p<\/jats:italic> = 0.013). After 1 year, all the positive patients showed a significant decrease in pancreatic uptake of 99mTc\u2010interleukin\u20102 (P\/B: 7.87 \u00b1 2.28 at diagnosis <jats:italic>vs<\/jats:italic> 5.00 \u00b1 1.23 after 1 year; <jats:italic>p<\/jats:italic> &lt; 0.0001 paired <jats:italic>t<\/jats:italic>\u2010test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>99mTc\u2010interleukin\u20102 scintigraphy at diagnosis of Type 1 diabetes may identify patients with pancreatic inflammation. In such patients, treated with nicotinamide at 25 mg\/kg, insulin requirement and pancreatic inflammation after 1 year were significantly reduced suggesting that IL2 scintigraphy may be of potential use for assessing the autoimmune phenomena in endocrine pancreas. 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