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To identify gene expression changes during this photoreceptor regeneration response, a microarray analysis was performed at five time points during the light treatment. The time course included an early time point during photoreceptor death (16 h), later time points during progenitor cell proliferation and migration (31, 51, and 68 h) and a 96 h time point, which likely corresponds to the initial photoreceptor differentiation. Mean expression values for each gene were calculated at each time point relative to the control (0 h light exposure) and statistical analysis by one\u2010way ANOVA identified 4567 genes exhibiting significant changes in gene expression along the time course. The genes within this data set were clustered based on their temporal expression patterns and proposed functions. Quantitative real\u2010time PCR validated the microarray expression profiles for selected genes, including <jats:italic>stat3<\/jats:italic> whose expression increased markedly during the light exposure. Based on immunoblots, both total and activated Stat3 protein expression also increased during the light treatment. Immunolocalization of Stat3 on retinal tissue sections demonstrated increased expression in photoreceptors and M\u00fcller glia by 16 h of light exposure. Some of the Stat3\u2010positive M\u00fcller cells expressed PCNA at 31 h, suggesting that Stat3 may play a role in signaling a subset of M\u00fcller cells to proliferate during the regeneration response. \u00a9 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007.<\/jats:p>","DOI":"10.1002\/dneu.20362","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T20:44:44Z","timestamp":1173213884000},"page":"1009-1031","source":"Crossref","is-referenced-by-count":185,"title":["Time course analysis of gene expression during light\u2010induced photoreceptor cell death and regeneration in <i>albino<\/i> zebrafish"],"prefix":"10.1002","volume":"67","author":[{"given":"Sean C.","family":"Kassen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Ramanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"T. 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