{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:13:15Z","timestamp":1792714395013,"version":"4.5.0"},"reference-count":175,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In general, neurons in the mature mammalian central nervous system (CNS) are unable to regenerate injured axons, and neurons that remain uninjured are unable to form novel connections that might compensate for ones that have been lost. As a result of this, victims of CNS injury, stroke, or certain neurodegenerative diseases are unable to fully recover sensory, motor, cognitive, or autonomic functions. Regenerative failure is related to a host of inhibitory signals associated with the extracellular environment and with the generally low intrinsic potential of mature CNS neurons to regenerate. Most research to date has focused on extrinsic factors, particularly the identification of inhibitory proteins associated with myelin, the perineuronal net, glial cells, and the scar that forms at an injury site. However, attempts to overcome these inhibitors have resulted in relatively limited amounts of CNS regeneration. Using the optic nerve as a model system, we show that with appropriate stimulation, mature neurons can revert to an active growth state and that when this occurs, the effects of overcoming inhibitory signals are enhanced dramatically. Similar conclusions are emerging from studies in other systems, pointing to a need to consider combinatorial treatments in the clinical setting. \u00a9 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007<\/jats:p>","DOI":"10.1002\/dneu.20515","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T18:34:53Z","timestamp":1179599693000},"page":"1148-1165","source":"Crossref","is-referenced-by-count":87,"title":["Combinatorial treatments for promoting axon regeneration in the CNS: Strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state"],"prefix":"10.1002","volume":"67","author":[{"given":"Larry I.","family":"Benowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1987.tb23661.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(01)32106-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2001.01387.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-16-07097.2002"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90015-2"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.130.4.969"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.3.3.363"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.45.29626"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02284793"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/82881"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-04-01303.2002"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/416636a"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8706"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/378498a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1995.1031"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00826-7"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04731.2001"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80681-9"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90212-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.106.4.1281"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00033-7"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/385434a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000219"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-10-03977.2002"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-19-08367.1999"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1245"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1064"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-23-09334.2001"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(02)00037-4"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6171034"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01150259"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-14-05810.1999"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80413-4"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80373-6"},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1523\/JNEUROSCI.23-02-00530.2003","article-title":"The L1 cell adhesion molecule is essential for topographic mapping of retinal axons","volume":"23","author":"Demyanenko GP","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3978"},{"key":"e_1_2_1_38_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1523\/JNEUROSCI.18-02-00779.1998","article-title":"Fetal spinal cord transplants support growth of supraspinal and segmental projections after cervical spinal cord hemisection in the neonatal rat","volume":"18","author":"Diener PS","year":"1998","journal-title":"J Neurosci"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00770-5"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90066-9"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7589"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20602"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-13-04975.2000"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04704.x"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81060-0"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-23-10346.2002"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5119-03.2004"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7822"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2774-04.2004"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-08876.2002"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053072"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01416.2003"},{"key":"e_1_2_1_53_1","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1242\/dev.124.17.3313","article-title":"Control of early cell death by BDNF in the chick retina","volume":"124","author":"Frade JM","year":"1997","journal-title":"Development"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80452-3"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00602-5"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1068428"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4390-03.2004"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/417547a"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000226"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-05-01479.1990"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971201)50:5<888::AID-JNR24>3.0.CO;2-W"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10207"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.05.009"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04089.x"},{"key":"e_1_2_1_65_1","first-page":"139","article-title":"The collagenous lesion scar\u2014An obstacle for axonal regeneration in brain and spinal cord injury","volume":"19","author":"Hermanns S","year":"2001","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01431"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/43441"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2806-05.2006"},{"key":"e_1_2_1_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81118-6"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03553.2002"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-005-0042-5"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090497"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04468.2002"},{"key":"e_1_2_1_74_1","doi-asserted-by":"crossref","first-page":"18320","DOI":"10.1073\/pnas.0605135103","article-title":"Mst3b,a purine\u2010sensitive Ste20\u2010like protein kinase, regulates axon outgrowth","volume":"103","author":"Irwin N","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00546-6"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(89)90262-6"},{"key":"e_1_2_1_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00147-8"},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00431-2"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1115462"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.868901"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302791"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-17-07537.1999"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-12-04615.2000"},{"key":"e_1_2_1_84_1","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1523\/JNEUROSCI.23-21-07830.2003","article-title":"Axon regeneration in goldfish and rat retinal ganglion cells: Differential responsiveness to carbohydrates and cAMP","volume":"23","author":"Li Y","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073031"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh706"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04034.x"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2002.1175"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1492-04.2004"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-04-00972.1991"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-06-02097.1998"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-11-03911.2001"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.5.1632"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-2023(02)00232-3"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5467-05.2006"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1995.1081"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-11-03398.1991"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90247-X"},{"key":"e_1_2_1_99_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.10.3537"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90695-J"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90172-8"},{"key":"e_1_2_1_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80586-3"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80414-6"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(02)00035-0"},{"key":"e_1_2_1_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00311-X"},{"key":"e_1_2_1_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/87415"},{"key":"e_1_2_1_107_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-27-09229.2003"},{"key":"e_1_2_1_108_1","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1523\/JNEUROSCI.08-12-04445.1988","article-title":"Changes in rapidly transported proteins in developing hamster retinofugal axons","volume":"8","author":"Moya KL","year":"1988","journal-title":"J Neurosci"},{"key":"e_1_2_1_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90042-6"},{"key":"e_1_2_1_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81063-6"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00702-X"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-23-10368.2002"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402595101"},{"key":"e_1_2_1_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01751"},{"key":"e_1_2_1_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(04)47005-8"},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-13-05393.2003"},{"key":"e_1_2_1_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10144"},{"key":"e_1_2_1_118_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0953-816X.2000.01398.x"},{"key":"e_1_2_1_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1056"},{"key":"e_1_2_1_120_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl015"},{"key":"e_1_2_1_121_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-21-08031.2000"},{"key":"e_1_2_1_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072699"},{"key":"e_1_2_1_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000287"},{"key":"e_1_2_1_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3269-04.2005"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00730-4"},{"key":"e_1_2_1_126_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111165498"},{"key":"e_1_2_1_127_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00560.x"},{"key":"e_1_2_1_128_1","volume-title":"Estudios Sobre la Degeneraci\u00f3n y Regeneraci\u00f3n del Sistema Nervioso","author":"Ramon Y","year":"1913"},{"key":"e_1_2_1_128_2","volume-title":"English translation: Degeneration and Regeneration of the Nervous System","author":"May RM","year":"1928"},{"key":"e_1_2_1_128_3","volume-title":"Cajal's Degeneration and Regeneration of the Nervous System","author":"DeFelipe J","year":"1991"},{"key":"e_1_2_1_129_1","first-page":"163","volume-title":"Spinal Cord Reconstruction","author":"Reier PJ","year":"1983"},{"key":"e_1_2_1_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/284264a0"},{"key":"e_1_2_1_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M100240200"},{"key":"e_1_2_1_132_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-11-03594.1990"},{"key":"e_1_2_1_133_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.11.4130"},{"key":"e_1_2_1_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480251209"},{"key":"e_1_2_1_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04334"},{"key":"e_1_2_1_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/367170a0"},{"key":"e_1_2_1_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/343269a0"},{"key":"e_1_2_1_138_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1993.tb00970.x"},{"key":"e_1_2_1_139_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02381.1988"},{"key":"e_1_2_1_140_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-09-02415.1985"},{"key":"e_1_2_1_141_1","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.1523\/JNEUROSCI.15-08-05514.1995","article-title":"Two factors secreted by the goldfish optic nerve induce retinal ganglion cells to regenerate axons in culture","volume":"15","author":"Schwalb JM","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_1_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00605-2"},{"key":"e_1_2_1_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.11.009"},{"key":"e_1_2_1_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01249-7"},{"key":"e_1_2_1_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-7431(03)00053-8"},{"key":"e_1_2_1_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1326"},{"key":"e_1_2_1_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00226-5"},{"key":"e_1_2_1_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1193"},{"key":"e_1_2_1_149_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.001015"},{"key":"e_1_2_1_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(85)91047-9"},{"key":"e_1_2_1_151_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5382.1515"},{"key":"e_1_2_1_152_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2111-05.2005"},{"key":"e_1_2_1_153_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3900-05.2006"},{"key":"e_1_2_1_154_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4464-04.2005"},{"key":"e_1_2_1_155_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.07-09-02894.1987"},{"key":"e_1_2_1_156_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.5.2395"},{"key":"e_1_2_1_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01176"},{"key":"e_1_2_1_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00867"},{"key":"e_1_2_1_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04419.x"},{"key":"e_1_2_1_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90930-X"},{"key":"e_1_2_1_161_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7200"},{"key":"e_1_2_1_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2003.08.017"},{"key":"e_1_2_1_163_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02430"},{"key":"e_1_2_1_164_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0715"},{"key":"e_1_2_1_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1045"},{"key":"e_1_2_1_166_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02284.2003"},{"key":"e_1_2_1_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1701"},{"key":"e_1_2_1_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00182-9"},{"key":"e_1_2_1_169_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-12-04744.1998"},{"key":"e_1_2_1_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409026102"},{"key":"e_1_2_1_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00225-3"},{"key":"e_1_2_1_172_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110301"},{"key":"e_1_2_1_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.05.011"},{"key":"e_1_2_1_174_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.21.8301"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.20515","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.20515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:25:17Z","timestamp":1694593517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.20515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,18]]},"references-count":175,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1002\/dneu.20515"],"URL":"https:\/\/doi.org\/10.1002\/dneu.20515","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,18]]}}}