{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T13:30:27Z","timestamp":1760707827685},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,5,24]],"date-time":"2007-05-24T00:00:00Z","timestamp":1179964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2007,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cell death is a nearly ubiquitous feature of the developing nervous system, and differential death in males and females contributes to several well studied sex differences in neuron number. Nonetheless, the functional importance of neuronal cell death has been subjected to few direct tests. <jats:italic>Bax<\/jats:italic>, a pro\u2010apoptotic protein, is required for cell death in many neural regions. Deletion of the <jats:italic>Bax<\/jats:italic> gene in mice increases neuron number in several areas and eliminates sex differences in cell number in the brain and spinal cord. Here, sexual and motor behaviors were examined in <jats:italic>Bax\u2212\/\u2212<\/jats:italic> mice and their wild\u2010type siblings to test the functional consequences of preventing <jats:italic>Bax<\/jats:italic>\u2010dependent cell death. Animals were gonadectomized in adulthood and provided with ovarian hormones or with testosterone for tests of feminine and masculine sexual behaviors, respectively. Wild\u2010type mice exhibited a sex difference in feminine sexual behavior, with high lordosis scores in females and low scores in males. This sex difference was eliminated by <jats:italic>Bax<\/jats:italic> deletion, with very low receptivity exhibited by both male and female <jats:italic>Bax\u2212\/\u2212<\/jats:italic> mice. Masculine sexual behavior was not sexually dimorphic among wild\u2010type mice, but mounts and pelvic thrusts were nearly eliminated in <jats:italic>Bax\u2212\/\u2212<\/jats:italic> mice of both sexes. Motor strength and performance at low speeds on a RotaRod apparatus did not differ by sex or <jats:italic>Bax<\/jats:italic> gene status. However, <jats:italic>Bax\u2212\/\u2212<\/jats:italic> animals exhibited impairments on the RotaRod at higher speeds. Thus, developmental cell death may be required for masculine and feminine sexual behaviors and the fine tuning of motor coordination. \u00a9 2007 Wiley Periodicals, Inc. 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