{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T18:16:59Z","timestamp":1760897819439},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T00:00:00Z","timestamp":1191456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously described the spontaneous regeneration of retinal ganglion cell axons after optic nerve (ON) transection in the adult <jats:italic>Gallotia galloti<\/jats:italic>. As neurotrophin\u20103 (NT\u20103) is involved in neuronal differentiation, survival and synaptic plasticity, we performed a comparative immunohistochemical study of NT\u20103 during the ontogeny and regeneration (after 0.5, 1, 3, 6, 9, and 12 months postlesion) of the lizard visual system to reveal its distribution and changes during these events. For characterization of NT\u20103<jats:sup>+<\/jats:sup> cells, we performed double labelings using the neuronal markers HuC\u2010D, Pax6 and parvalbumin (Parv), the microglial marker tomato lectin or Lycopersicon esculentum agglutinin (LEA), and the astroglial markers vimentin (Vim) and glial fibrillary acidic protein (GFAP). Subpopulations of retinal and tectal neurons were NT\u20103<jats:sup>+<\/jats:sup> from early embryonic stages to adulthood. Nerve fibers within the retinal nerve fiber layer, both plexiform layers and the retinorecipient layers in the optic tectum (OT) were also stained. In addition, NT\u20103<jats:sup>+<\/jats:sup>\/GFAP<jats:sup>+<\/jats:sup> and NT\u20103<jats:sup>+<\/jats:sup>\/Vim<jats:sup>+<\/jats:sup> astrocytes were detected in the ON, chiasm and optic tract in postnatal and adult lizards. At 1 month postlesion, abundant NT\u20103<jats:sup>+<\/jats:sup>\/GFAP<jats:sup>+<\/jats:sup> astrocytes and NT\u20103<jats:sup>\u2212<\/jats:sup>\/LEA<jats:sup>+<\/jats:sup> microglia\/macrophages were stained in the lesioned ON, whereas NT\u20103 became downregulated in the experimental retina and OT. Interestingly, at 9 and 12 months postlesion, the staining in the experimental retina resembled that in control animals, whereas bundles of putative regrown fibers showed a disorganized staining pattern in the OT. Altogether, we demonstrate that NT\u20103 is widely distributed in the lizard visual system and its changes after ON transection might be permissive for the successful axonal regrowth. \u00a9 2007 Wiley Periodicals, Inc. 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