{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:02:25Z","timestamp":1789750945673,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T00:00:00Z","timestamp":1199923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stromal cell\u2010derived factor 1 (SDF\u20101) and its receptor CXCR4 influence neuronal migration and have been identified in nasal regions. Gonadotropin releasing hormone\u20101 (GnRH\u20101) neurons migrate from nasal regions into the developing forebrain, where postnatally they control reproduction. This study examined the role of SDF\u20101\/CXCR4 in development of the GnRH\u20101\/olfactory systems. Migrating GnRH\u20101 neurons were CXCR4 immunopositive as were the fibers along which they migrate. SDF\u20101 transcripts were detected in olfactory epithelium and vomeronasal organ, while SDF\u20101 immunoreactivity highlighted the GnRH\u20101 migratory pathway. CXCR4\u2010deficient mice showed a decrease in GnRH\u20101 cells at the nasal forebrain junction and in brain, but the overall migratory pathway remained intact, no ectopic GnRH\u20101 cells were detected and olfactory axons reached the olfactory bulb. To further characterize the influence of SDF\u20101\/CXCR4 in the GnRH\u20101 system, nasal explants were used. CXCR4 expression\n                    <jats:italic>in vitro<\/jats:italic>\n                    was similar to that\n                    <jats:italic>in vivo.<\/jats:italic>\n                    SDF\u20101 was detected in a dorsal midline cell cluster as well as in migrating GnRH\u20101 cells. Treatment of explants with bicyclam AMD3100, a CXCR4 antagonist, attenuated GnRH\u20101 neuronal migration and sensory axon outgrowth. Moreover, the number of GnRH\u20101 neurons in the explant periphery was reduced. The effects were blocked by coincubation with SDF\u20101. Removal of midline SDF\u20101 cells did not alter directional outgrowth of olfactory axons. These results indicate that SDF\u20101\/CXCR4 signaling in not necessary for olfactory axon guidance but rather influences sensory axon extension and GnRH\u20101 neuronal migration, and maintains GnRH\u20101 neuronal expression as the cells move away from nasal pit regions. \u00a9 2008 Wiley Periodicals, Inc. Develop Neurobiol 2008\n                  <\/jats:p>","DOI":"10.1002\/dneu.20594","type":"journal-article","created":{"date-parts":[[2008,1,10]],"date-time":"2008-01-10T11:18:46Z","timestamp":1199963926000},"page":"487-503","source":"Crossref","is-referenced-by-count":46,"title":["CXCR4\/SDF\u20101 system modulates development of GnRH\u20101 neurons and the olfactory system"],"prefix":"10.1002","volume":"68","author":[{"given":"Yoko","family":"Toba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean D.","family":"Tiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Wray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.18.4249"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(00)00338-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4631-04.2005"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.3.1254"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052144"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01360.2003"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)00021-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.07.004"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1319"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-07-02560.1998"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410100365"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0649-04.2004"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960226)366:1<1::AID-CNE1>3.0.CO;2-7"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00117-3"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.14.1824"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9896"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.5.1823"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00121-5"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00894.x"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10139"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092013799"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9448"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9405"},{"key":"e_1_2_1_25_1","first-page":"400","article-title":"Signals on the move:chemokine receptors and organogenesis in zebrafish","volume":"21","author":"Perlin JR","year":"2007","journal-title":"Sci STKE"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01029.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20236"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mn.7800200"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/338161a0"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1728-06.2006"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000110)416:2<201::AID-CNE6>3.0.CO;2-Z"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1523\/JNEUROSCI.21-03-00934.2001","article-title":"Differing, spatially restricted roles of ionotropic glutamate receptors in regulating the migration of gnrh neurons during embryogenesis","volume":"21","author":"Simonian SX","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.1.223"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(00)00136-X"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1677\/JME-06-0032"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05123.2003"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.01.002"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00685.x"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1275"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10546"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.346205"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04378.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01247-4"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3022(02)00001-8"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(88)90103-9"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.8132"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1994.1320"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/31269"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.20594","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.20594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T13:14:06Z","timestamp":1699967646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.20594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,10]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/dneu.20594"],"URL":"https:\/\/doi.org\/10.1002\/dneu.20594","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1,10]]}}}