{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:55:52Z","timestamp":1791122152573,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T00:00:00Z","timestamp":1204848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Olfactory sensory neurons (OSNs) in the nose form precise connections with neurons in the brain. However, mechanisms that account for the formation of such precise neuronal connections are incompletely understood. Recent studies implicate the function of Wnt growth factors in the formation of neuronal connections. To assess the role of Wnt signaling in the olfactory system, we examined the expression of \u03b2\u2010galactosidase (\u03b2\u2010gal) in the TOPGAL mouse, a transgenic strain in which \u03b2\u2010gal expression reports the activation of the canonical Wnt signaling pathway. In the olfactory epithelium, no \u03b2\u2010gal expression was observed at any developmental stages. In the olfactory bulb (OB), \u03b2\u2010gal expression was observed in a population of cells located at the interface of the olfactory nerve layer and the glomerular layer. The \u03b2\u2010gal expression was developmentally regulated with the peak expression occurring at late embryonic and early postnatal stages and a greatly reduced expression in adulthood. Further, forced OSN regeneration and subsequent reinnervation of the OB led to a reactivation of \u03b2\u2010gal expression in mature animals. The temporal coincidence between the peak of \u03b2\u2010gal expression and formation of OSN connections, together with the spatial localization of these cells, suggests a potential role of these cells and canonical Wnt signaling in the formation of OSN connections in the OB during development and regeneration. \u00a9 2008 Wiley Periodicals, Inc. 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