{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:59:39Z","timestamp":1761058779102},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T00:00:00Z","timestamp":1206316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is currently unclear whether retinal ganglion cell (RGC) axon regeneration depends on down\u2010regulation of axon growth\u2010inhibitory proteins, and to what extent outgrowth\u2010promoting substrates contribute to RGC axon regeneration in reptiles. We performed an immunohistochemical study of the regulation of the axon growth\u2010inhibiting extracellular matrix molecules tenascin\u2010R and chondroitin sulphate proteoglycan (CSPG), the axon outgrowth\u2010promoting extracellular matrix proteins fibronectin and laminin, and the axonal tenascin\u2010R receptor protein F3\/contactin during RGC axon regeneration in the lizard, <jats:italic>Gallotia galloti<\/jats:italic>. Tenascin\u2010R and CSPG were expressed in an extracellular matrix\u2010, oligodendrocyte\/myelin\u2010 and neuron\u2010associated pattern and up\u2010regulated in the regenerating optic pathway. The expression pattern of tenascin\u2010R was not indicative of a role in channeling or restriction of re\u2010growing RGC axons. Up\u2010regulation of fibronectin, laminin, and F3\/contactin occurred in spatiotemporal patterns corresponding to tenascin\u2010R expression. Moreover, we analyzed the influence of substrates containing tenascin\u2010R, fibronectin, and laminin on outgrowth of regenerating lizard RGC axons. <jats:italic>In vitro<\/jats:italic> regeneration of RGC axons was not inhibited by tenascin\u2010R, and further improved on mixed substrates containing tenascin\u2010R together with fibronectin or laminin. These results indicate that RGC axon regeneration in <jats:italic>Gallotia galloti<\/jats:italic> does not require down\u2010regulation of tenascin\u2010R or CSPG. Presence of tenascin\u2010R is insufficient to prevent RGC axon growth, and concomitant up\u2010regulation of axon growth\u2010promoting molecules like fibronectin and laminin may override the effects of neurite growth inhibitors on RGC axon regeneration. Up\u2010regulation of contactin in RGCs suggests that tenascin\u2010R may have an instructive function during axon regeneration in the lizard optic pathway. \u00a9 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008<\/jats:p>","DOI":"10.1002\/dneu.20624","type":"journal-article","created":{"date-parts":[[2008,3,24]],"date-time":"2008-03-24T16:16:36Z","timestamp":1206375396000},"page":"899-916","source":"Crossref","is-referenced-by-count":22,"title":["Tenascin\u2010R and axon growth\u2010promoting molecules are up\u2010regulated in the regenerating visual pathway of the lizard (<i>Gallotia galloti<\/i>)"],"prefix":"10.1002","volume":"68","author":[{"given":"Dirk M.","family":"Lang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximina","family":"Monzon\u2010Mayor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"del Mar Romero\u2010Aleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Yanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penka","family":"Pesheva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1526-06.2006"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1523\/JNEUROSCI.11-03-00626.1991","article-title":"Growth of regenerating goldfish axons is inhibited by rat oligodendrocytes and CNS myelin but not but not by goldfish optic nerve tract oligodendrocytelike cells and fish CNS myelin","volume":"11","author":"Bastmeyer M","year":"1991","journal-title":"J Neurosci"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01187117"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771503770802925"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970106)377:1<105::AID-CNE10>3.0.CO;2-P"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1523\/JNEUROSCI.22-03-00842.2002","article-title":"Repellent guidance of regenerating optic axons by chondroitin sulphate glycosaminoglycans in zebrafish","volume":"22","author":"Becker CG","year":"2002","journal-title":"J Neurosci"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1523\/JNEUROSCI.19-02-00813.1999","article-title":"Tenascin\u2010R inhibits the growth of optic fibers in vitro but is rapidly eliminated during nerve regeneration in the salamander Pleurodeles waltl","volume":"19","author":"Becker CG","year":"1999","journal-title":"J Neurosci"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1523\/JNEUROSCI.23-15-06232.2003","article-title":"Tenascin\u2010R as a repellent guidance molecule for developing optic axons in zebrafish","volume":"23","author":"Becker CG","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.03.003"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(20000215)29:4<330::AID-GLIA4>3.0.CO;2-L"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903600409"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.008"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7059"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2006.09.004"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20299"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.371"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01181566"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)37025-0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.04.013"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2006.19.9.1050423"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903600405"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09276.2003"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2003.09.021"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msg241"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199805)23:1<61::AID-GLIA6>3.0.CO;2-7"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.10099"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1523\/JNEUROSCI.15-01-00099.1995","article-title":"CNS myelin and oligodendrocytes of the Xenopus spinal cord\u2014but not optic nerve\u2014are nonpermissive for axon growth","volume":"15","author":"Lang DM","year":"1995","journal-title":"J Neurosci"},{"key":"e_1_2_1_29_1","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1523\/JNEUROSCI.23-21-07830.2003","article-title":"Axon regeneration in goldfish and rat retinal ganglion cells: Differential responsiveness to carbohydrates and cAMP","volume":"23","author":"Li Y","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(03)00071-4"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.445"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.2108\/zsj.13.813"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(93)90243-K"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(01)32069-1"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00061-1"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.05.008"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.4.1765"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02075-8"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1055"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91345-0"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.08.009"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.07.057"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7573"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903430205"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5382.1515"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523899164083"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-6-60"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-11-07500.1995"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312466200"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1956"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.34.24357"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.20624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.20624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T18:14:25Z","timestamp":1699985665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.20624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,24]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1002\/dneu.20624"],"URL":"https:\/\/doi.org\/10.1002\/dneu.20624","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,24]]}}}