{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T18:28:20Z","timestamp":1780511300452,"version":"3.54.1"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T00:00:00Z","timestamp":1209427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although considerable progress has been made in understanding the roles of olfactory receptor neurons (ORNs) and projection neurons (PNs) in <jats:italic>Drosophila<\/jats:italic> antennal lobe (AL) development, the roles of glia have remained largely mysterious. Here, we show that during <jats:italic>Drosophila<\/jats:italic> metamorphosis, a population of midline glial cells in the brain undergoes extensive cellular remodeling and is closely associated with the collateral branches of ORN axons. These glial cells are required for ORN axons to project across the midline and establish the contralateral wiring in the ALs. We find that <jats:italic>Neuroglian<\/jats:italic> (<jats:italic>Nrg<\/jats:italic>), the <jats:italic>Drosophila<\/jats:italic> homolog of the vertebrate cell adhesion molecule, L1, is expressed and functions in the midline glial cells to regulate their proper development. Loss of <jats:italic>Nrg<\/jats:italic> causes the disruption in glial morphology and the agenesis of the antennal commissural tract. Our genetic analysis further demonstrates that the functions of <jats:italic>Nrg<\/jats:italic> in the midline glia require its ankyrin\u2010binding motif. We propose that <jats:italic>Nrg<\/jats:italic> is an important regulator of glial morphogenesis and axon guidance in AL development. \u00a9 2008 Wiley Periodicals, Inc. Develop Neurobiol, 2008.<\/jats:p>","DOI":"10.1002\/dneu.20644","type":"journal-article","created":{"date-parts":[[2008,4,29]],"date-time":"2008-04-29T15:17:09Z","timestamp":1209482229000},"page":"1029-1045","source":"Crossref","is-referenced-by-count":22,"title":["The L1\u2010CAM, Neuroglian, functions in glial cells for <i>Drosophila<\/i> antennal lobe development"],"prefix":"10.1002","volume":"68","author":[{"given":"Weitao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huey","family":"Hing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,4,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.01.030"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00356"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5383-05.2006"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/368208a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90029-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1523\/JNEUROSCI.20-12-04515.2000","article-title":"The L1\u2010type cell adhesion molecule neuroglian 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