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Because brain\u2010derived neurotrophic factor (BDNF) is considered the major neurotrophin participating in vertebrate visual system development and promotes RGC survival, we investigated its distribution using dual\u2010labeling immunohistochemistry for neuronal and glial markers. We examined the developing and regenerating lizard visual system at 1, 3, 6, 9, and 12 months postlesion to comparatively evaluate BDNF expression patterns. BDNF was detected from midembryonic stages (E35) in both retinal plexiform layers, and in radial glial processes in the tectum. Moreover, RGC axon staining was detected at late prenatal stages (E39), showing a transient punctate staining which progressed in a temporo\u2010spatial pattern that was similar to myelination. Strong expression in RGC axons was maintained in adults. However, transient downregulation of BDNF staining occurred on the experimental side one month after ON transection followed by a gradual recovery with extensive punctate\/swelling distribution and persistent upregulation at 12 months. Conversely, quantitative PCR analysis for 1 and 12 months regenerate lizards showed downregulation of the ratio of BDNF mRNA expression at 12 months and nonsignificant changes of NT\u20103 transcripts. In summary, we demonstrate that BDNF and NT\u20103 are abundantly expressed during lizard visual system ontogeny and regeneration suggesting their participation inthe development, maintenance and plasticity of the system. \u00a9 2011Wiley Periodicals, Inc.Develop Neurobiol 71: 836\u2013853, 2011<\/jats:p>","DOI":"10.1002\/dneu.20939","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T22:11:34Z","timestamp":1308607894000},"page":"836-853","source":"Crossref","is-referenced-by-count":10,"title":["Expression of BDNF and NT\u20103 during the ontogeny and regeneration of the lacertidian (<i>Gallotia galloti<\/i>) visual 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