{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:40:11Z","timestamp":1786977611155,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>The serum protein fetuin\u2010A is essential for mineral homeostasis and shows immunomodulatory functions, for example by binding to TGF superfamily proteins. It proved neuroprotective in a rat stroke model and reduced lethality after systemic lipopolysaccharide challenge in mice. Serum fetuin\u2010A concentrations are highest during intrauterine life. Different species show intrauterine cerebral fetuin\u2010A immunoreactivity, suggesting a contribution to brain development. We therefore aimed at specifying fetuin\u2010A immunoreactivity in brains of newborn rats (age P0\u2013P28) and human neonates (20\u201340 weeks of gestation). In humans and rats, fetuin\u2010A was found in cortex, white matter, subplate, hippocampus, subventricular zone, and ependymal cells which supports a global role for brain function. In rats, overall fetuin\u2010A immunoreactivity decreased with age. At P0 fetuin\u2010A immunoreactivity affected most brain structures. Thereafter, it became increasingly restricted to distinct cells of the hippocampus, cingular gyrus, periventricular stem cell layer, and ependyma. In ependymal cells the staining pattern complied with active transependymal transport from cerebrospinal fluid. Double immunofluorescence studies revealed colocalization with NeuN (mature neurons), beta III tubulin (immature neurons), GFAP (astrocytes), and CD68 (activated microglia). This points to a role of fetuin\u2010A in different brain functional systems. In human neonatal autopsy cases, frequently affected from severe neurological and non\u2010neurological diseases, fetuin\u2010A immunoreactivity was heterogeneous and much less associated with age than in healthy tissues studied earlier, suggesting an impact of exogeneous noxious factors on fetuin\u2010A regulation. Further research on the role of fetuin\u2010A in the neonatal brain during physiological and pathological conditions is recommended. \u00a9 2012 Wiley Periodicals, Inc. 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