{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:43:06Z","timestamp":1792082586021,"version":"4.4.0"},"reference-count":92,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,3]],"date-time":"2013-12-03T00:00:00Z","timestamp":1386028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ethanol is known as a potent teratogen having adverse effects on brain and behavior. However, some of the behavioral deficits caused by fetal alcohol exposure and well expressed in juveniles ameliorate with maturation may suggest some kind of functional recovery occurring during postnatal development. The aim of this study was to reexamine age\u2010dependent behavioral impairments in fetal\u2010alcohol rats and to investigate the changes in neurogenesis and gross morphology of the hippocampus during a protracted postnatal period searching for developmental deficits and\/or delays that would correlate with behavioral impairments in juveniles and for potential compensatory processes responsible for their amelioration in adults. Ethanol was delivered to the pregnant dams by intragastric intubation throughout 7\u201321 gestation days at daily dose of 6 g\/kg. Isocaloric intubation and intact control groups were included. Locomotor activity, anxiety, and spatial learning tasks were applied to juvenile and young\u2010adult rats from all groups. Unbiased stereological estimates of hippocampal volumes, the total number of pyramidal and granular cells, and double cortin expressing neurons were carried out for postnatal days (PDs) PD1, PD10, PD30, and PD60. Alcohol insult during second trimester equivalent caused significant deficits in the spatial learning in juvenile rats; however, its effect on hippocampal morphology was limited to a marginally lower number of granular cells in dentate gyrus (DG) on PD30. Thus, initial behavioral deficits and the following functional recovery in fetal\u2010alcohol subjects may be due to more subtle plastic changes within the hippocampal formation but also in other structures of the extended hippocampal circuit. Further investigation is required. \u00a9 2013 Wiley Periodicals, Inc. Develop Neurobiol 74: 498\u2013513, 2014<\/jats:p>","DOI":"10.1002\/dneu.22143","type":"journal-article","created":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T11:02:35Z","timestamp":1383044555000},"page":"498-513","source":"Crossref","is-referenced-by-count":29,"title":["Examination of Age\u2010dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats"],"prefix":"10.1002","volume":"74","author":[{"given":"Birsen","family":"Elibol\u2010Can","sequence":"first","affiliation":[{"name":"Department of Biological Sciences Middle East Technical University Ankara 06531 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Dursun","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics Uskudar University \u0130stanbul 34662 Turkey"},{"name":"Neuropsychopharmacology Application and Research Center Uskudar University \u0130stanbul 34662 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilknur","family":"Telkes","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Middle East Technical University Ankara 06531 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertugrul","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Physiology Istanbul Medipol University \u0130stanbul 34083 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Canan","sequence":"additional","affiliation":[{"name":"Department of Physiology Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Ankara 06050 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Jakubowska\u2010Dogru","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Middle East Technical University Ankara 06531 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1982.tb04993.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(95)98055-6"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005286"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.earlhumdev.2005.07.005","article-title":"Prenatal stress, the hypothalamic\u2010pituitary\u2010adrenal axis, and fetal and infant neurobehaviour","volume":"81","author":"Austin MP","year":"2005","journal-title":"Early Hum Dev."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804650106"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7079742"},{"key":"e_1_2_5_8_1","first-page":"83","article-title":"Timetables of neurogenesisin the human brain based on experimentally determined patterns in the rat","volume":"14","author":"Bayer SA","year":"1993","journal-title":"Neurotoxicol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901050305"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.04.024"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00049538108254702"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1990.tb00455.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420440203"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresprot.2004.09.003"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10874"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.06.006"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.05.066"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.11.004"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb12983.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(79)90022-7"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(90)90094-S"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.09.001"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01557.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2012.12.013"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20648"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.06.003"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.04.011"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(90)90060-R"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04611.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.10.026"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.08.007"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(90)90070-S"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb04246.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1987.tb02837.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.1999.00457.x"},{"key":"e_1_2_5_36_1","first-page":"1","article-title":"A study of the rat's behavior in a field: A contribution to method in comparative psychology","volume":"6","author":"Hall CS","year":"1932","journal-title":"Univ Calif Publ Psychol"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807059105"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91291-9"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237141"},{"issue":"572","key":"e_1_2_5_40_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.2006.105254","article-title":"Fetal programming of hypothalamo\u2010pituitary\u2010adrenal function: Prenatal stress and glucocorticoids","volume":"1","author":"Kapoor A","year":"2006","journal-title":"J Physiol"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0036-1"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(87)90220-2"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1975.tb00820.x"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.268"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06608.x"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.20.11032"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00177912"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(03)00030-8"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06543.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05763.x"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(00)00133-6"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.10077"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2189-7_5"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(01)00168-4"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.10072"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01014.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20155"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2012.00045"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03826.x"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03786.x"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/1029842021000010875"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb04312.x"},{"key":"e_1_2_5_64_1","first-page":"45","volume-title":"The rat brain in stereotaxic coordinates","author":"Paxinos G","year":"2007"},{"key":"e_1_2_5_65_1","first-page":"63","volume-title":"Atlas of the developing mouse brain","author":"Paxinos G","year":"2007"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01272-X"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(99)00017-3"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20164"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000828)424:3<397::AID-CNE2>3.0.CO;2-A"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.10.001"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001118"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn109"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890903531582"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2008.05.001"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.018"},{"key":"e_1_2_5_77_1","first-page":"118","article-title":"Fetal alcohol spectrum disorders: From research to policy","volume":"33","author":"Thomas JD","year":"2010","journal-title":"Alcohol Res Health"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(03)00074-6"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(00)00263-1"},{"key":"e_1_2_5_80_1","first-page":"35","article-title":"The effect of methylphenidate on overactivity in rats prenatally exposed to alcohol","volume":"5","author":"Ulug S","year":"1983","journal-title":"Neurobehav Toxicol Teratol"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2003.11.011"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22753"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-9668.82312"},{"key":"e_1_2_5_84_1","first-page":"23","article-title":"Effects of short\u2010term prenatal alcohol exposure on maze, activity, and olfactory orientation performance in rats","volume":"8","author":"Vorhees CV","year":"1986","journal-title":"Neurobehav Toxicol Teratol"},{"key":"e_1_2_5_85_1","first-page":"4","article-title":"Fetal alcohol spectrum disorders: Research challenges and opportunities","volume":"34","author":"Warren KR","year":"2011","journal-title":"Alcohol Res Health"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01054.x"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092310411"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00277-8"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.104.1.116"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.08.006"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0088-11.2011"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80039-7"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(95)00008-K"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22143","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:22:02Z","timestamp":1696623722000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,3]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1002\/dneu.22143"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22143","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,3]]}}}