{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T01:17:51Z","timestamp":1778462271826,"version":"3.51.4"},"reference-count":75,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T00:00:00Z","timestamp":1396569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DC010433"],"award-info":[{"award-number":["R01DC010433"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002607","name":"American Speech-Language-Hearing Foundation","doi-asserted-by":"publisher","award":["Research Grant for New Investigators"],"award-info":[{"award-number":["Research Grant for New Investigators"]}],"id":[{"id":"10.13039\/100002607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Although individuals with autism are known to have significant communication problems, the cellular mechanisms responsible for impaired communication are poorly understood. Valproic acid (VPA) is an anticonvulsant that is a known risk factor for autism in prenatally exposed children. Prenatal VPA exposure in rats causes numerous neural and behavioral abnormalities that mimic autism. We predicted that VPA exposure may lead to auditory processing impairments which may contribute to the deficits in communication observed in individuals with autism. In this study, we document auditory cortex responses in rats prenatally exposed to VPA. We recorded local field potentials and multiunit responses to speech sounds in primary auditory cortex, anterior auditory field, ventral auditory field. and posterior auditory field in VPA exposed and control rats. Prenatal VPA exposure severely degrades the precise spatiotemporal patterns evoked by speech sounds in secondary, but not primary auditory cortex. This result parallels findings in humans and suggests that secondary auditory fields may be more sensitive to environmental disturbances and may provide insight into possible mechanisms related to auditory deficits in individuals with autism. \u00a9 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 972\u2013986, 2014<\/jats:p>","DOI":"10.1002\/dneu.22175","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T08:23:10Z","timestamp":1395130990000},"page":"972-986","source":"Crossref","is-referenced-by-count":47,"title":["Degraded auditory processing in a rat model of autism limits the speech representation in non\u2010primary auditory cortex"],"prefix":"10.1002","volume":"74","author":[{"given":"C.T.","family":"Engineer","sequence":"first","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.M.","family":"Centanni","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.W.","family":"Im","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Borland","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.A.","family":"Moreno","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.S.","family":"Carraway","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.G.","family":"Wilson","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Kilgard","sequence":"additional","affiliation":[{"name":"School of Behavioral and Brain Sciences The University of Texas at Dallas Richardson Texas 75080"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"crossref","unstructured":"AbramsDA LynchCJ ChengKM PhillipsJ SupekarK RyaliS UddinLQ et al.2013.Underconnectivity between voice\u2010selective cortex and reward circuitry in children with autism.Proc Natl Acad Sci110:12060\u201312065.","DOI":"10.1073\/pnas.1302982110"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.1.15"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.2004.t01-1-00303.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901940312"},{"key":"e_1_2_5_6_1","unstructured":"BaioJ.2012. Prevalence of Autism Spectrum Disorders: Autism and Developmental Disabilities Monitoring Network 14 Sites United States 2008. Morbidity and Mortality Weekly Report. Surveillance Summaries Vol 61. Centers for Disease Control and Prevention."},{"key":"e_1_2_5_7_1","first-page":"1","article-title":"Impairment of cortical GABAergic synaptic transmission in an environmental rat model of autism","volume":"1","author":"Banerjee A","year":"2012","journal-title":"Int J Neuropsychopharmacol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.11.2117"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2004.04.001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-5597(92)90021-3"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00092.2013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0835631100"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0835631100"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2270"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1994.tb11858.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.026"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.10.021"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078607"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2109"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00088"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2003.12.011"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.09.031"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1291"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.01.011"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2013.05.004"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01057.2010"},{"key":"e_1_2_5_27_1","first-page":"1303","article-title":"Speech representation and transformation using adaptive interpolation of weighted spectrum: Vocoder revisited","volume":"2","author":"Kawahara H","year":"1997","journal-title":"Proc ICASSP"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00061-1"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12147"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32800fef9d"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2004.00384.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr335"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101576"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2108"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.05.013"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.01.1.1.006.2007"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301453"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(92)90183-I"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.4001"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70323-X"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq352"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803531"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164105X25117"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.7.489"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820d62c7"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617710001359"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.11.008"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200504040-00021"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.02.014"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs045"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90581-9"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01298.2006"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.12.015"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01309.2006"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-012-0328-1"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370206"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00191-2"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2005.tb01190.x"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-011-1324-8"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.04.004.2008"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhm117"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.01.015"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2013.01.004"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-009-0737-0"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-005-0043-4"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300518"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300767"},{"key":"e_1_2_5_68_1","first-page":"531","article-title":"Nociceptive changes in rats after prenatal exposure to valproic acid","volume":"53","author":"Schneider T","year":"2001","journal-title":"Polish J Pharmacol"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4330-05.2006"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07887.x"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(03)00194-3"},{"key":"e_1_2_5_72_1","first-page":"1","article-title":"Enhanced long term microcircuit plasticity in the valproic acid animal model of autism","volume":"1","author":"Silva GT","year":"2009","journal-title":"Front Synapt Neurosci"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00037.2011"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2006.08.007"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-7687.2008.00697.x"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00188.x"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:24:40Z","timestamp":1696555480000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,4]]},"references-count":75,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1002\/dneu.22175"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22175","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,4]]}}}