{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:30:47Z","timestamp":1790303447162,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T00:00:00Z","timestamp":1399593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council Taiwan","doi-asserted-by":"publisher","award":["99-2628-B-002-052-MY3"],"award-info":[{"award-number":["99-2628-B-002-052-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Serotonin (5\u2010HT) plays important roles during neural development. Administration of selective serotonin reuptake inhibitor (SSRI)\u2010type medication during gestation may influence the maturation of the fetal brain and subsequent brain functions. To mimic the condition of late\u2010gestation SSRI exposure, we administered fluoxetine (FLX) in neonatal rats during the first postnatal week, which roughly corresponds to the third trimester period of human gestation. FLX\u2010exposed adult male rats exhibited reduced locomotor activity and depression\u2010like behaviors. Furthermore, sensorimotor gating capacity was also impaired. Interestingly, increased social interaction was noticed in FLX\u2010exposed rats. When the levels of 5\u2010HT and tryptophan hydroxylase were examined, no significant changes were found in FLX rats compared to control (CON) rats. The behavioral phenotypes of FLX rats suggested malfunction of the limbic system. Dendritic architectures of neurons in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) were examined. Layer II\/III mPFC pyramidal neurons in FLX rats had exuberant dendritic branches with elongated terminal segments compared to those in CON rats. In BLA pyramidal neurons, the dendritic profiles were comparable between the two groups. However, in FLX rats, the density of dendritic spines was reduced in both mPFC and BLA. Together, our results demonstrated the long\u2010lasting effects of early FLX treatment on emotional and social behaviors in adult rats in which impaired neuronal structure in the limbic system was also noticed. The risk of taking SSRI\u2010type antidepressants during pregnancy should be considered. \u00a9 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 1038\u20131051, 2014<\/jats:p>","DOI":"10.1002\/dneu.22185","type":"journal-article","created":{"date-parts":[[2014,4,27]],"date-time":"2014-04-27T07:54:45Z","timestamp":1398585285000},"page":"1038-1051","source":"Crossref","is-referenced-by-count":56,"title":["Long\u2010term consequences of neonatal fluoxetine exposure in adult rats"],"prefix":"10.1002","volume":"74","author":[{"given":"Meng\u2010Ching","family":"Ko","sequence":"first","affiliation":[{"name":"Graduate Institute of Anatomy and Cell Biology National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas Jyuhn\u2010Hsiarn","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Environmental Health and Occupational Medicine National Health Research Institutes Miaoli Taiwan"},{"name":"Department of Neurology and Environmental and Occupational Medicine National Taiwan University Hospital Taipei 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