{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:03:34Z","timestamp":1792782214897,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS047663"],"award-info":[{"award-number":["NS047663"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG023477"],"award-info":[{"award-number":["AG023477"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oregon Tax Check-off Program for Alzheimers Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Accumulations of Tau, a microtubule\u2010associated protein (MAP), into neurofibrillary tangles is a hallmark of Alzheimer's disease and other tauopathies. However, the mechanisms leading to this pathology are still unclear: the aggregates themselves could be toxic or the sequestration of Tau into tangles might prevent Tau from fulfilling its normal functions, thereby inducing a loss of function defect. Surprisingly, the consequences of losing normal Tau expression\n                    <jats:italic>in vivo<\/jats:italic>\n                    are still not well understood, in part due to the fact that Tau knockout mice show only subtle phenotypes, presumably due to the fact that mammals express several MAPs with partially overlapping functions. In contrast, flies express fewer MAP, with Tau being the only member of the Tau\/MAP2\/MAP4 family. Therefore, we used\n                    <jats:italic>Drosophila<\/jats:italic>\n                    to address the physiological consequences caused by the loss of Tau. Reducing the levels of fly Tau (dTau) ubiquitously resulted in developmental lethality, whereas deleting Tau specifically in neurons or the eye caused progressive neurodegeneration. Similarly, chromosomal mutations affecting dTau also caused progressive degeneration in both the eye and brain. Although photoreceptor cells initially developed normally in dTau knockdown animals, they subsequently degenerated during late pupal stages whereas weaker dTau alleles caused an age\u2010dependent defect in rhabdomere structure. Expression of wild type human Tau partially rescued the neurodegenerative phenotype caused by the loss of endogenous dTau, suggesting that the functions of Tau proteins are functionally conserved from flies to humans. \u00a9 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 1210\u20131225, 2014\n                  <\/jats:p>","DOI":"10.1002\/dneu.22199","type":"journal-article","created":{"date-parts":[[2014,6,7]],"date-time":"2014-06-07T03:40:37Z","timestamp":1402112437000},"page":"1210-1225","source":"Crossref","is-referenced-by-count":46,"title":["Loss of tau results in defects in photoreceptor development and progressive neuronal degeneration in\n                    <scp>\n                      <i>Drosophila<\/i>\n                    <\/scp>"],"prefix":"10.1002","volume":"74","author":[{"given":"Bonnie J.","family":"Bolkan","sequence":"first","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University Portland Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Kretzschmar","sequence":"additional","affiliation":[{"name":"Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University Portland Oregon 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0188-12.2012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-11-1004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0228-12.2012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2008.10.014"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64296-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn326"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.05.112"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009480"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.04.047"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi3010818"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb02494.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.6.1179"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-6-1-204"},{"issue":"2","key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1242\/jcs.109.2.467","article-title":"MAP\u20101B\/TAU functional redundancy during laminin\u2010enhanced axonal growth","author":"DiTella MC","year":"1996","journal-title":"J Cell Sci 109"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00616"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06663.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15712"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950130506"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)38495-8"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2928"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/369488a0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00487-7"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81169-1"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0486-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00706-7"},{"key":"e_1_2_6_27_1","first-page":"873270","article-title":"Lessons from tau\u2010deficient mice","author":"Ke YD","year":"2012","journal-title":"Int J Alzheimers Dis"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.12.042"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-19-07425.1997"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100103"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021218"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M803519200"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.1121"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2613"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.480230602"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0207-8"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00061-5"},{"key":"e_1_2_6_38_1","first-page":"134","article-title":"Microtubule\u2010associated proteins and the determination of neuronal form","volume":"84","author":"Matus A","year":"1990","journal-title":"J Physiol (Paris)"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb34421.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl608"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90518-1"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.5.989"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(90)90013-E"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00052.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.5.1858"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001225)428:4<630::AID-CNE4>3.0.CO;2-X"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.11.4070"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062382"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4922-11.2012"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22199","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T11:13:57Z","timestamp":1696590837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,18]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1002\/dneu.22199"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22199","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,18]]}}}