{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T01:17:26Z","timestamp":1788139046624,"version":"build-2803163510"},"reference-count":96,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T00:00:00Z","timestamp":1426723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CNPq (J.Q. and G.Z.R.), FAPESC (J.Q.), InstitutoC\u00e9rebro e Mente, UNESC (J.Q.), and L'Or\u00e9al\/UNESCO\/ABC Brazil Fellowship for Women in Science 2011 (G.Z.R.)"},{"name":"Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School in Houston (The Center for Experimental Models in Psychiatry, USA)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ketamine, an antagonist of <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate receptors, has produced rapid antidepressant effects in patients with depression, as well as in animal models. However, the extent and duration of the antidepressant effect over longer periods of time has not been considered. This study evaluated the effects of single dose of ketamine on behavior and oxidative stress, which is related to depression, in the brains of adult rats subjected to maternal deprivation. Deprived and nondeprived Wistar rats were divided into four groups nondeprived\u2009+\u2009saline; nondeprived\u2009+\u2009S\u2010ketamine (15 mg\/kg); deprived\u2009+\u2009saline; deprived\u2009+\u2009S\u2010ketamine (15 mg\/kg). A single dose of ketamine or saline was administrated during the adult phase, and 14 days later depressive\u2010like behavior was assessed. In addition, lipid damage, protein damage, and antioxidant enzyme activities were evaluated in the rat brain. Maternal deprivation induces a depressive\u2010like behavior, as verified by an increase in immobility and anhedonic behavior. However, a single dose of ketamine was able to reverse these alterations, showing long\u2010term antidepressant effects. The brains of maternally deprived rats had an increase in protein oxidative damage and lipid peroxidation, but administration of a single dose of ketamine reversed this damage. The activities of antioxidant enzymes superoxide dismutase and catalase were reduced in the deprived rat brains. However, ketamine was also able to reverse these changes. In conclusion, these findings indicate that a single dose of ketamine is able to induce long\u2010term antidepressant effects and protect against neural damage caused by oxidative stress in adulthood rats following maternal deprivation. \u00a9 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1268\u20131281, 2015<\/jats:p>","DOI":"10.1002\/dneu.22283","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T23:14:52Z","timestamp":1425078892000},"page":"1268-1281","source":"Crossref","is-referenced-by-count":77,"title":["A single dose of <scp>S<\/scp>\u2010ketamine induces long\u2010term antidepressant effects and decreases oxidative stress in adulthood rats following maternal deprivation"],"prefix":"10.1002","volume":"75","author":[{"given":"Gislaine Z.","family":"R\u00e9us","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"},{"name":"Department of Psychiatry and Behavioral Sciences Center for Experimental Models in Psychiatry Medical School, The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelise S.","family":"Carlessi","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Titus","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Center for Experimental Models in Psychiatry Medical School, The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M.","family":"Abelaira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleide M.","family":"Ign\u00e1cio","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaine R.","family":"da Luz","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz I.","family":"Matias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Bruchchen","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drielly","family":"Florentino","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Cl\u00ednica e Experimental, Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade do Sul de Santa Catarina Tubar\u00e3o SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriele","family":"Vieira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Fisiopatologia Cl\u00ednica e Experimental, Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade do Sul de Santa Catarina Tubar\u00e3o SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricia","family":"Petronilho","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Center for Experimental Models in Psychiatry Medical School, The University of Texas Health Science Center at Houston Houston Texas"},{"name":"Laborat\u00f3rio de Fisiopatologia Cl\u00ednica e Experimental, Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade do Sul de Santa Catarina Tubar\u00e3o SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Quevedo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neuroci\u00eancias, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Unidade Acad\u00eamica de Ci\u00eancias da Sa\u00fade, Universidade do Extremo Sul Catarinense Crici\u00fama SC Brazil"},{"name":"Department of Psychiatry and Behavioral Sciences Center for Experimental Models in Psychiatry Medical School, The University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.003"},{"key":"e_1_2_5_3_1","article-title":"Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury","author":"Abdul\u2010Muneer PM","journal-title":"Mol Neurobiol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2013-1098"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.01.019"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(92)90043-G"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.07.024"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2010.494183"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10130"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470110539.ch5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.04.002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(00)00199-3"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.006"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00161"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-3124(08)60057-7"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00101.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2010.05.011"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/713803728"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.09.018"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9375-x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245592"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.90"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86135-I"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.1223"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/35041687"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1373.1999.d01-140.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-014-3664-5"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1014"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.07.027"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2009.01.004"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.3\/pgorwood"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705776"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.017"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1212704"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2009.11.003"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.105"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2014.23.1.28"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12040531"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.03.081"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.031"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.105"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86141-H"},{"key":"e_1_2_5_45_1","first-page":"959","volume-title":"mTOR\u2010dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","author":"Li N","year":"2010"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_5_47_1","first-page":"358","volume":"54","author":"Lucca G","year":"2009","journal-title":"Effects of chronic mild stress on the oxidative parameters in the rat brain"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2008.11.002"},{"key":"e_1_2_5_49_1","first-page":"460","article-title":"Low S(+) ketamine doses: A review","volume":"55","author":"Luft A","year":"2005","journal-title":"Rev Bras Anestesiol"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.05.004"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.04.004"},{"key":"e_1_2_5_52_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00213-014-3669-0","article-title":"D\u2010serine plasma concentration is a potential biomarker of (R,S)\u2010ketamine antidepressant response in subjects with treatment\u2010resistant depression","volume":"232","author":"Moaddel R","year":"2014","journal-title":"Psychopharmacology (Berl)"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.09.006"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.05.007"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.09.018"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145707008401"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00057-W"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12118"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-012-0322-7"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.04.027"},{"key":"e_1_2_5_61_1","volume-title":"The Rat Brain: Stereotaxic Coordinates","author":"Paxinos G","year":"1986"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/266730a0"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328362066d"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.08.041"},{"key":"e_1_2_5_65_1","article-title":"Minocycline protects against oxidative damage and alters energy metabolism parameters in the brain of rats subjected to chronic mild stress","author":"R\u00e9us GZ","journal-title":"Metab Brain Dis"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011-012-9281-2"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.11.044"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.10.022"},{"key":"e_1_2_5_69_1","article-title":"Ketamine treatment partly reverses alterations in brain derived\u2010neurotrophic factor, oxidative stress and energy metabolism parameters induced by an animal model of depression","author":"R\u00e9us GZ","journal-title":"Curr Neurovasc Res"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.5.13109"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0364-3"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.02.024"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.04.010"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5745"},{"key":"e_1_2_5_75_1","first-page":"00277","article-title":"Folic acid prevents depressive\u2010like behavior induced by chronic corticosterone treatment in mice","volume":"0091","author":"Rosa PB","year":"2014","journal-title":"Pharmacol Biochem Behav"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.11.011"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00315"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145713000047"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.203"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.05.022"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.889853"},{"key":"e_1_2_5_82_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000363340","article-title":"Manganese superoxide dismutase gene expression and cognitive functions in recurrent depressive disorder","volume":"70","author":"Talarowska M","year":"2014","journal-title":"Neuropsychobiology"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001094"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049677"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.09.001"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.04.052"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.71"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087097"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.12.007"},{"key":"e_1_2_5_90_1","unstructured":"World Health Organization.2012.Media Centre Fact Sheet No. 369.www.who.int\/mediacentre\/factsheets\/fs369\/en\/."},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.11.027"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-012-0226-2"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00693-1"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.11.010"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.856"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.12.010"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.05.010"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22283","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:30:00Z","timestamp":1696602600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,19]]},"references-count":96,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/dneu.22283"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22283","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,19]]}}}