{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:08:20Z","timestamp":1790798900102,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T00:00:00Z","timestamp":1453420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Faculty of the University of Oslo"},{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"Southern and Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation pour la Recherche M\u00e9dicale","award":["SPE20100518439"],"award-info":[{"award-number":["SPE20100518439"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>To assess the organization and functional development of vestibulospinal inputs to cervical motoneurons (MNs), we have used electrophysiology (ventral root and electromyographic [EMG] recording), calcium imaging, trans\u2010synaptic rabies virus (RV) and conventional retrograde tracing and immunohistochemistry in the neonatal mouse. By stimulating the VIIIth nerve electrically while recording synaptically mediated calcium responses in MNs, we characterized the inputs from the three vestibulospinal tracts, the separate ipsilateral and contralateral medial vestibulospinal tracts (iMVST\/cMVST) and the lateral vestibulospinal tract (LVST), to MNs in the medial and lateral motor columns (MMC and LMC) of cervical segments. We found that ipsilateral inputs from the iMVST and LVST were differentially distributed to the MMC and LMC in the different segments, and that all contralateral inputs to MMC and LMC MNs in each segment derive from the cMVST. Using trans\u2010synaptic RV retrograde tracing as well as pharmacological manipulation of VIIIth nerve\u2010elicited synaptic responses, we found that a substantial proportion of inputs to both neck and forelimb extensor MNs was mediated monosynaptically, but that polysynaptic inputs were also significant. By recording EMG responses evoked by natural stimulation of the vestibular apparatus, we found that vestibular\u2010mediated motor output to the neck and forelimb musculature became more robust during the first 10 postnatal days, concurrently with a decrease in the latency of MN discharge evoked by VIIIth nerve electrical stimulation. Together, these results provide insight into the complexity of vestibulospinal connectivity in the cervical spinal cord and a cogent demonstration of the functional maturation that vestibulospinal connections undergo postnatally. \u00a9 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1061\u20131077, 2016<\/jats:p>","DOI":"10.1002\/dneu.22375","type":"journal-article","created":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T14:54:59Z","timestamp":1451746499000},"page":"1061-1077","source":"Crossref","is-referenced-by-count":44,"title":["Early postnatal maturation in vestibulospinal pathways involved in neck and forelimb motor control"],"prefix":"10.1002","volume":"76","author":[{"given":"Fran\u00e7ois M.","family":"Lambert","sequence":"first","affiliation":[{"name":"Laboratory of Neural Development and Optical Recording (NDEVOR) Division of Physiology Department of Molecular Medicine Institute of Basic Medical Sciences, University of Oslo Oslo Norway"},{"name":"Institut De Neurosciences Cognitives Et Int\u00e9gratives D'aquitaine University of Bordeaux, CNRS UMR 5287 Bordeaux 33076 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bras","sequence":"additional","affiliation":[{"name":"Institut De Neurosciences De La Timone, CNRS and Aix Marseille Universit\u00e9 Marseille Cedex 05 13385 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cardoit","sequence":"additional","affiliation":[{"name":"Institut De Neurosciences Cognitives Et Int\u00e9gratives D'aquitaine University of Bordeaux, CNRS UMR 5287 Bordeaux 33076 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Vinay","sequence":"additional","affiliation":[{"name":"Institut De Neurosciences De La Timone, CNRS and Aix Marseille Universit\u00e9 Marseille Cedex 05 13385 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Coulon","sequence":"additional","affiliation":[{"name":"Institut De Neurosciences De La Timone, CNRS and Aix Marseille Universit\u00e9 Marseille Cedex 05 13385 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C.","family":"Glover","sequence":"additional","affiliation":[{"name":"Laboratory of Neural Development and Optical Recording (NDEVOR) Division of Physiology Department of Molecular Medicine Institute of Basic Medical Sciences, University of Oslo Oslo Norway"},{"name":"Norwegian Center for Stem Cell Research Department of Immunology and Transfusion Medicine Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91252-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125555"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-0031-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981207)402:1<111::AID-CNE8>3.0.CO;2-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-408088-1.00015-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071701"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06407.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00550-8"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00024-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22717"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.12.001"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.6.2241"},{"key":"e_1_2_6_14_1","first-page":"517","article-title":"Development of posture in the rat","volume":"53","author":"Geisler HC","year":"1993","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"e_1_2_6_15_1","first-page":"1","article-title":"Retrograde and anterograde axonal tracing with fluorescent dextran\u2010amines in the embryonic nervous system","volume":"30","author":"Glover JC.","year":"1995","journal-title":"Neurosci Protocols"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.03.065"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2611-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03910.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0696-05.2005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.195644"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.234609"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5188-14.2015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02259112"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991108)414:1<80::AID-CNE7>3.0.CO;2-E"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.05.018"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-013-0536-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903210210"},{"key":"e_1_2_6_28_1","first-page":"295","article-title":"Input\u2010output relations of Deiters' lateral vestibulospinal neurons with different structures of the brain","volume":"138","author":"Sarkisian VH.","year":"2000","journal-title":"Arch Ital Biol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.77.3.1234"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)51017-3"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-0030-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.10.054"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00058"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.09.001"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1995.tb01028.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1155\/NP.2005.131"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(85)90441-5"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1990.64.6.1695"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25231.x"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22375","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dneu.22375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:01:34Z","timestamp":1694350894000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,22]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/dneu.22375"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22375","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"value":"1932-8451","type":"print"},{"value":"1932-846X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,22]]}}}