{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:28:56Z","timestamp":1792661336835,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Adult neurogenesis attracts broad attention as a possible cure for neurological disorders. However, its regulatory mechanism is still unclear. Therefore, they have been studying the cell proliferation mechanisms of neural stem cells (NSCs) using zebrafish, which have high regenerative potential in the adult brain. The presence of neuroepithelial\u2010type NSCs in the optic tectum of adult zebrafish has been previously reported. In the present study, it was first confirmed that NSCs in the optic tectum decrease or increase in proportion to projection of the optic nerves from the retina. At 4 days after optic nerve crush (ONC), BrdU\u2010positive cells decreased in the optic tectum's operation side. In contrast, at 3 weeks after ONC, BrdU\u2010positive cells increased in the optic tectum's operation side. To study the regulatory mechanisms, they focused on the BDNF\/TrkB system as a regulatory factor in the ONC model. It was found that <jats:italic>bdnf was<\/jats:italic> mainly expressed in the periventricular gray zone (PGZ) of the optic tectum by using <jats:italic>in situ<\/jats:italic> hybridization. Interestingly, expression level of <jats:italic>bdnf<\/jats:italic> significantly decreased in the optic tectum at 4 days after ONC, and its expression level tended to increase at 3 weeks after ONC. They conducted rescue experiments using a TrkB agonist and confirmed that decrease of NSC proliferation in the optic tectum by ONC was rescued by TrkB signal activation, suggesting stimuli\u2010dependent regulation of NSC proliferation in the optic tectum of adult zebrafish. \u00a9 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 419\u2013437, 2017<\/jats:p>","DOI":"10.1002\/dneu.22423","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T13:20:37Z","timestamp":1470230437000},"page":"474-482","source":"Crossref","is-referenced-by-count":11,"title":["Optic nerve input\u2010dependent regulation of neural stem cell proliferation in the optic tectum of adult zebrafish"],"prefix":"10.1002","volume":"77","author":[{"given":"Yuki","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Life Science and Medical Bio\u2010Science Waseda University Shinjuku\u2010Ku Tokyo 162\u20108480 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Life Science and Medical Bio\u2010Science Waseda University Shinjuku\u2010Ku Tokyo 162\u20108480 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Life Science and Medical Bio\u2010Science Waseda University Shinjuku\u2010Ku Tokyo 162\u20108480 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideomi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Life Science and Medical Bio\u2010Science Waseda University Shinjuku\u2010Ku Tokyo 162\u20108480 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Life Science and Medical Bio\u2010Science Waseda University Shinjuku\u2010Ku Tokyo 162\u20108480 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21121"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20615"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.08.002"},{"key":"e_1_2_6_5_1","volume-title":"Real\u2010time PCR: advanced methods series","author":"Dorak MT","year":"2006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24173"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1056"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2010.01268.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.03.040"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2010.03.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt098"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.2015"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20473"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2006.06.002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.045"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(83)90008-5"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18262-4_15"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20506"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.03-05-01077.1983"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1523\/JNEUROSCI.03-05-01092.1983","article-title":"Postembryonic growth of the optic tectum in goldfish. 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