{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T14:56:46Z","timestamp":1758121006881,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 20020130100198BA"],"award-info":[{"award-number":["UBACyT 20020130100198BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The olfactory epithelium (OE) has the remarkable capability to constantly replace olfactory receptor neurons (ORNs) due to the presence of neural stem cells (NSCs). For this reason, the OE provides an excellent model to study neurogenesis and neuronal differentiation. In the present work, we induced neuronal degeneration in the OE of <jats:italic>Xenopus laevis<\/jats:italic> larvae by bilateral axotomy of the olfactory nerves. We found that axotomy induces specific\u2010 neuronal death through apoptosis between 24 and 48h post\u2010injury. In concordance, there was a progressive decrease of the mature\u2010ORN marker OMP until it was completely absent 72h post\u2010injury. On the other hand, neurogenesis was evident 48h post\u2010injury by an increase in the number of proliferating basal cells as well as NCAM\u2010180\u2013 GAP\u201043+ immature neurons. Mature ORNs were replenished 21 days post\u2010injury and the olfactory function was partially recovered, indicating that new ORNs were integrated into the olfactory bulb glomeruli. Throughout the regenerative process no changes in the expression pattern of the neurotrophin Brain Derivate Neurotrophic Factor were observed. Taken together, this work provides a sequential analysis of the neurodegenerative and subsequent regenerative processes that take place in the OE following axotomy. \u00a9 2017 Wiley Periodicals, Inc. 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