{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:10:16Z","timestamp":1740147016786,"version":"3.37.3"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,17]],"date-time":"2017-11-17T00:00:00Z","timestamp":1510876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC\u2010006876","HL107152 (Programs of Excellence in Glycosciences Grant)","GM075168"],"award-info":[{"award-number":["DC\u2010006876","HL107152 (Programs of Excellence in Glycosciences Grant)","GM075168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In the brain, the extracellular matrix (ECM) plays a central role during neural development and thus modulates critical\u2010period regulated behavioral ontogeny. The major components of the ECM are glycosaminoglycans (GAGs) including chondroitin sulfate (CS). However, the specific roles of GAGs in behavioral development are largely unknown. It has been shown that xylosides affect the biological functions of GAGs through modulating GAG biosynthesis. Particularly, xylosides affect GAG biosynthesis through priming of GAG chains (priming activity), competing with endogenous core proteins that carry GAG initiation sites (decoy activity), or both. Using birdsong as our model, we investigated, for the first time, how xyloside\u2010mediated modulation of GAG biogenesis affects song development. Xylosides infused into motor cortex of juvenile birds alter song development by specifically affecting ontogeny of the stereotyped sequence rather than the acoustic structure of syllables. Further analyses reveal that observed changes can be attributed to the priming activity rather than the decoy activity of xylosides. Collectively, these results suggest that regulation of GAG biogenesis through chemical biology approaches may allow promising therapeutic interventions of critical\u2010period\u2010dependent central nervous system plasticity. \u00a9 2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1401\u20131412, 2017<\/jats:p>","DOI":"10.1002\/dneu.22547","type":"journal-article","created":{"date-parts":[[2017,10,21]],"date-time":"2017-10-21T08:22:39Z","timestamp":1508574159000},"page":"1401-1412","source":"Crossref","is-referenced-by-count":0,"title":["Regulation of glycosaminoglycan biogenesis is critical for sensitive\u2010period\u2010dependent vocal ontogeny"],"prefix":"10.1002","volume":"77","author":[{"given":"Caitlin P.","family":"Mencio","sequence":"first","affiliation":[{"name":"Interdepartmental Program in Neuroscience University of Utah Salt Lake City Utah 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vy","family":"My Tran","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry University of Utah Salt Lake City Utah 84112"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritza V.","family":"Quintero","sequence":"additional","affiliation":[{"name":"Department of Medicinal 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