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In this study, we analyzed the effects of artificial rearing on the open field and burial behavioral tests and on GFAP, c\u2010Fos immunoreactivity, and glucose metabolism measured in anxiety\u2010related brain areas. Artificial rearing of male rats was performed by supplying artificial milk through a cheek cannula and tactile stimulation, mimicking the mother's licking to rat pups from the fourth postnatal day until weaning. Tactile stimulation was applied twice a day, at morning and at night, by means of a camel brush on the rat anogenital area. As compared to mother reared rats, greater aggressiveness, and boldness, stereotyped behavior (burial conduct) was observed in artificially reared rats which occurred in parallel to a reduction of GFAP immunoreactivity in somatosensory cortex, c\u2010Fos immunoreactivity at the amygdala and primary somatosensory cortex, and lower metabolism in amygdala (as measured by 2\u2010deoxi\u20102\u2010[<jats:sup>18<\/jats:sup>fluoro]\u2010<jats:sc>d<\/jats:sc>\u2010glucose uptake, assessed by microPET imaging). These results could suggest that tactile and\/or chemical<jats:italic>stimuli<\/jats:italic>from the mother and littermates carry relevant information for the proper development of the central nervous system, particularly in brain areas involved with emotions and social relationships of the rat. \u00a9 2017 Wiley Periodicals, Inc. 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