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These syndromes are accompanied by brain malformations like type II lissencephaly in the cerebral cortex with characteristic overmigrations of neurons through the breaches of the pial basement membrane. The signaling pathways activated by laminin receptors, dystroglycan and integrins, control the integrity of the basement membrane, and their malfunctioning may underlie the pathologies found in the rise of defects reminiscent of these syndromes. Similar defects in corticogenesis and neuromuscular disorders were found in mice when RIC8A was specifically removed from neural precursor cells. RIC8A regulates a subset of G\u2010protein \u03b1 subunits and in several model organisms, it has been reported to participate in the control of cell division, signaling, and migration.<\/jats:p><jats:p>Here, we studied the role of RIC8A in the development of the brain, muscles, and eyes of the neural precursor\u2010specific conditional <jats:italic>Ric8a<\/jats:italic> knockout mice. The absence of RIC8A severely affected the attachment and positioning of radial glial processes, Cajal\u2010Retzius\u2019 cells, and the <jats:italic>arachnoid trabeculae<\/jats:italic>, and these mice displayed additional defects in the lens, skeletal muscles, and heart development. All the discovered defects might be linked to aberrancies in cell adhesion and migration, suggesting that RIC8A has a crucial role in the regulation of cell\u2013extracellular matrix interactions and that its removal leads to the phenotype characteristic to type II lissencephaly\u2010associated diseases. \u00a9 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 374\u2013390, 2018<\/jats:p>","DOI":"10.1002\/dneu.22578","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T09:28:42Z","timestamp":1517304522000},"page":"374-390","source":"Crossref","is-referenced-by-count":4,"title":["Targeted deletion of RIC8A in mouse neural precursor cells interferes with the development of the brain, eyes, and muscles"],"prefix":"10.1002","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0629-2601","authenticated-orcid":false,"given":"Keiu","family":"Kask","sequence":"first","affiliation":[{"name":"Institute of Molecular and Cell Biology, University of Tartu, 23 Riia St Tartu 51010 Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tikker","sequence":"additional","affiliation":[{"name":"Department of Biosciences University of Helsinki, P.O. 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