{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:35:52Z","timestamp":1766136952738,"version":"3.37.3"},"reference-count":169,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MH100556","DK078938","NS085910"],"award-info":[{"award-number":["MH100556","DK078938","NS085910"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Social impairment is one of the major symptoms in multiple psychiatric disorders, including autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut microbiota in social development, but these mechanisms remain unclear. This review focuses on two strategies adopted to elucidate the complicated relationship between gut bacteria and host social behavior. In a top\u2010down approach, researchers have attempted to correlate behavioral abnormalities with altered gut microbial profiles in rodent models of ASD, including BTBR mice, maternal immune activation (MIA), maternal valproic acid (VPA) and maternal high\u2010fat diet (MHFD) offspring. In a bottom\u2010up approach, researchers use germ\u2010free (GF) animals, antibiotics, probiotics or pathogens to manipulate the intestinal environment and ascertain effects on social behavior. The combination of both approaches will hopefully pinpoint specific bacterial communities that control host social behavior. Further discussion of how brain development and circuitry is impacted by depletion of gut microbiota is also included. The converging evidence strongly suggests that gut microbes affect host social behavior through the alteration of brain neural circuits. Investigation of intestinal microbiota and host social behavior will unveil any bidirectional communication between the gut and brain and provide alternative therapeutic targets for ASD. \u00a9 2018 Wiley Periodicals, Inc. Develop Neurobiol 78: 474\u2013499, 2018<\/jats:p>","DOI":"10.1002\/dneu.22581","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T09:16:47Z","timestamp":1517995007000},"page":"474-499","source":"Crossref","is-referenced-by-count":55,"title":["Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder"],"prefix":"10.1002","volume":"78","author":[{"given":"Brittany D.","family":"Needham","sequence":"first","affiliation":[{"name":"Division of Biology and Biological Engineering California Institute of Technology, 1200 E. California Boulevard Pasadena California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering California Institute of Technology, 1200 E. California Boulevard Pasadena California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-1881","authenticated-orcid":false,"given":"Wei\u2010Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Biology and Biological Engineering California Institute of Technology, 1200 E. California Boulevard Pasadena California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.09.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-22"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/319760"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06127.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.182"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.29719"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-010-1006-y"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020100"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199909)35:2<146::AID-DEV7>3.0.CO;2-G"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.10.023"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04467.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.02.019"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.063"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0771-7"},{"key":"e_1_2_9_17_1","article-title":"Disruptive physiology: Olfaction and the microbiome\u2010gut\u2010brain axis","author":"Bienenstock J","year":"2017","journal-title":"Biol Rev Camb Philos Soc"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.11.061"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2010.03.005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1525"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102999108"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009759"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304270"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.50"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240659"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1878C"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.12.031"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.06.027"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.10.020"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.06.021"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36250"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0314"},{"key":"e_1_2_9_34_1","first-page":"53643","article-title":"Induction of maternal immune activation in mice at mid\u2010gestation stage with viral mimic poly(I:C)","author":"Chow KH","year":"2016","journal-title":"J Vis Expe"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2270"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0330-z"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.77"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45356"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0900N"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.01.014"},{"volume-title":"Sickness Behavior: A Neuroimmune\u2010Based Response to Infectious Disease","year":"2000","author":"Dantzer R","key":"e_1_2_9_41_1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076993"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8735"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.12.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.12.005"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.06.010"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.65"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.04.004"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010529108"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.001"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.12.054"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3194"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4257-13.2014"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2011.03.007"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2016.10.019"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.02.020"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.13442"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113026"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.07.008"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.202515"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2004.09.002"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.08.009"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.09.020"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/aur.237"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.017"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.04.002"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13028"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.100"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.42"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202556109"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.024"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11234"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4994"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.03.005"},{"key":"e_1_2_9_75_1","unstructured":"Investigators A.a.D.D.M.N.S.Y.P. 2014. Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years \u2014 Autism and Developmental Disabilities Monitoring Network 11 Sites United States 2010. In: Prevention C.f.D.C.a. (Ed.) Surveillance Summaries pp.1\u201321."},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0225-7"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068322"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0156-9"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.11.018"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104927"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.12.018"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23910"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23089"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.5b01025"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.187"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110474108"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.3402\/mehd.v26.26914"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2583"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15062"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.036"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/4441022a"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.126"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1659"},{"key":"e_1_2_9_94_1","article-title":"Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder","author":"Lombardo MV","year":"2017","journal-title":"Mol Psychiatry"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2286-1"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11550"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.25887"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13291"},{"key":"e_1_2_9_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1238677"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws433"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.06.019"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4889"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00278-13"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.01.011"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2017.80"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.040"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2007.00330.x"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/dev.20130"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.10.018"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.10.012"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3083"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-017-0121-4"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf3951"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.09.049"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00170255"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.07.030"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617710001359"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1603001"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2014.33"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01620.x"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-016-0099-3"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.06.026"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.03.033"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.12.023"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7003"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46101-0"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.51"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.12.016"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.03.001"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.7"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00128.2012"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.235"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003020"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.06.069"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171643"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3918"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-016-2825-4"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003067"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1619312114"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300518"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.16"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009906107"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2851"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.371"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302985111"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2017.09.013"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.189"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2014.00147"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.07.009"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.063388"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2015.04.008"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.10.023"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2017.06.009"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199605)29:4<353::AID-DEV4>3.0.CO;2-P"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306477110"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138293"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05224"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4481"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-017-0125-0"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02354-0"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2015.10.005"},{"key":"e_1_2_9_162_1","first-page":"3","article-title":"Application of novel PCR\u2010based methods for detection, quantitation, and phylogenetic characterization of Sutterella species in intestinal biopsy samples from children with autism and gastrointestinal disturbances","author":"Williams BL","year":"2012","journal-title":"MBio"},{"key":"e_1_2_9_163_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00582.x"},{"key":"e_1_2_9_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.02.005"},{"key":"e_1_2_9_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.11.007"},{"key":"e_1_2_9_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3353"},{"key":"e_1_2_9_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45942"},{"key":"e_1_2_9_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.047"},{"key":"e_1_2_9_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29998"},{"key":"e_1_2_9_170_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-013-2016-3"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdneu.22581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:33:05Z","timestamp":1694655185000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":169,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/dneu.22581"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22581","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"type":"print","value":"1932-8451"},{"type":"electronic","value":"1932-846X"}],"subject":[],"published":{"date-parts":[[2018,2,20]]}}}