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Following a peripheral lesion, a robust axonal growth program is initiated, whereas neurons of the central nervous system do not mount an effective regenerative response. Increasing the neuron\u2010intrinsic regenerative response would therefore be one way to promote axonal regeneration in the injured central nervous system. The large\u2010diameter sensory neurons located in the dorsal root ganglia are pseudo\u2010unipolar neurons that project one axon branch into the spinal cord, and, via the dorsal column to the brain stem, and a peripheral process to the muscles and skin. Dorsal root ganglion neurons are ideally suited to study the neuron\u2010intrinsic injury response because they exhibit a successful growth response following peripheral axotomy, while they fail to do so after a lesion of the central branch in the dorsal column. The dorsal column injury model allows the neuron\u2010intrinsic regeneration response to be studied in the context of a spinal cord injury. Here we will discuss the advantages and disadvantages of this model. We describe the surgical methods used to implement a lesion of the ascending fibers, the anatomy of the sensory afferent pathways and anatomical, electrophysiological, and behavioral techniques to quantify regeneration and functional recovery. Subsequently we review the results of experimental interventions in the dorsal column lesion model, with an emphasis on the molecular mechanisms that govern the neuron\u2010intrinsic injury response and manipulations of these after central axotomy. Finally, we highlight a number of recent advances that will have an impact on the design of future studies in this spinal cord injury model, including the continued development of adeno\u2010associated viral vectors likely to improve the genetic manipulation of dorsal root ganglion neurons and the use of tissue clearing techniques enabling 3D reconstruction of regenerating axon tracts. \u00a9 2018 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 00: 000\u2013000, 2018<\/jats:p>","DOI":"10.1002\/dneu.22601","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T05:27:36Z","timestamp":1525238856000},"page":"926-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Dorsal Column Lesion Model of Spinal Cord Injury and Its Use in Deciphering the Neuron\u2010Intrinsic Injury Response"],"prefix":"10.1002","volume":"78","author":[{"given":"Callan L.","family":"Attwell","sequence":"first","affiliation":[{"name":"Laboratory for Regeneration of Sensorimotor Systems Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Science, Meibergdreef 47 Amsterdam 1105BA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"van Zwieten","sequence":"additional","affiliation":[{"name":"Laboratory for Regeneration of Sensorimotor Systems Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Science, Meibergdreef 47 Amsterdam 1105BA The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8341-1096","authenticated-orcid":false,"given":"Joost","family":"Verhaagen","sequence":"additional","affiliation":[{"name":"Laboratory for Regeneration of Sensorimotor Systems Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Science, Meibergdreef 47 Amsterdam 1105BA The Netherlands"},{"name":"Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, De Boelelaan 1085 Amsterdam 1081HV The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R. 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