{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:47:37Z","timestamp":1793598457346,"version":"4.5.0"},"reference-count":78,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:00:00Z","timestamp":1539907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The X\u2010linked gene cyclin\u2010dependent kinase\u2010like 5 (\n                    <jats:italic>CDKL5<\/jats:italic>\n                    ) encodes a serine\/threonine kinase abundantly expressed in the brain. Mutations in\n                    <jats:italic>CDKL5<\/jats:italic>\n                    have been associated with neurodevelopmental disorders characterized by early\u2010onset epileptic encephalopathy and severe intellectual disability, suggesting that CDKL5 plays important roles in brain development and function. Recent studies using cultured neurons, knockout mice, and human iPSC\u2010derived neurons have demonstrated that CDKL5 regulates axon outgrowth, dendritic morphogenesis, and synapse formation. The role of CDKL5 in maintaining synaptic function in the mature brain has also begun to emerge. Moreover, mouse models that are deficient for CDKL5 recapitulate some of the key clinical phenotypes in human patients. Here we review these findings related to the function of CDKL5 in the brain and discuss the underlying molecular and cellular mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/dneu.22639","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T07:10:28Z","timestamp":1537773028000},"page":"8-19","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Molecular and Synaptic Bases of CDKL5 Disorder"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-0149","authenticated-orcid":false,"given":"Yong\u2010Chuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Qi","family":"Xiong","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,19]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091613"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"issue":"7","key":"e_1_2_3_4_1","first-page":"233","article-title":"The role of the striatum in social behavior","volume":"10","author":"B\u00e1ez\u2010Mendoza R.","year":"2013","journal-title":"Frontiers in 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