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Patients with <jats:styled-content style=\"fixed-case\">RTT<\/jats:styled-content> develop symptoms after 6\u201318 months of age, exhibiting characteristic movement deficits, such as ambulatory difficulties and loss of hand skills, in addition to breathing abnormalities and intellectual disability. Given the striking psychomotor dysfunction, numerous studies have investigated the underlying neurochemical and circuit mechanisms from different aspects. Here, I review the evidence linking Me<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>2 deficiency to alterations in neurotransmission and neural circuits that govern the psychomotor function and discuss a recently identified pathological origin underlying the psychomotor deficits in <jats:styled-content style=\"fixed-case\">RTT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/dneu.22651","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T03:43:18Z","timestamp":1542253398000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Psychomotor Dysfunction in Rett Syndrome: Insights into the Neurochemical and Circuit Roots"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-9614","authenticated-orcid":false,"given":"Wenlin","family":"Liao","sequence":"first","affiliation":[{"name":"Institute of Neuroscience 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903600310"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/73949"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2003.14.3.207"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1153252"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405063200"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09582"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_2_9_12_1","first-page":"1717","article-title":"Dopaminergic 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