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The development of radiolabeled positron emission tomography (<jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>) ligands for amyloid plaques and tau tangles enables the longitudinal assessment of the spatial pattern of their accumulation in relation to symptomatology. Recent work indicates that amyloid pathology develops 15\u201320 years before neurodegeneration and symptom onset in the sporadic and autosomal dominant forms of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, while tau pathology correlates more closely with symptomatic stages evidenced by cognitive decline and dementia. Recent work on <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> biomarkers in <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> illustrates similarities between <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> and sporadic <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. It may soon be possible to apply recently developed staging classifications to <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> to obtain a more nuanced understanding of the development <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> and to provide more accurate diagnosis and prognosis in the clinic.<\/jats:p>","DOI":"10.1002\/dneu.22658","type":"journal-article","created":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T09:49:11Z","timestamp":1544262551000},"page":"711-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tau <scp>PET<\/scp> Imaging for Staging of Alzheimer's Disease in Down Syndrome"],"prefix":"10.1002","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-2094","authenticated-orcid":false,"given":"Michael 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