{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:53:19Z","timestamp":1747147999190,"version":"3.40.5"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perinatal neurodevelopment involves extensive formation of neural connections and onset of activity\u2010dependent gene expression for synaptic function and plasticity. Exposure to psychostimulants at this stage imposes significant risks for developing cognitive and affective disorders later in life. However, how developmental exposure to psychostimulants may induce long\u2010lasting molecular changes relevant to neural circuit function remains incompletely understood. In this study, we investigated the impacts of psychostimulant amphetamine on the activity\u2010dependent induction of synaptic adaptor molecule <jats:italic>Arc<\/jats:italic> in the frontal cortex of neonatal mice. We found that transient exposure to amphetamine not only amplifies activity\u2010dependent <jats:italic>Arc <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression immediately, but also potentiates subsequent induction of <jats:italic>Arc <\/jats:italic><jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> in the absence of amphetamine. This priming effect is associated with a rapid and persistent increase in histone mono\u2010methylation (H3K4me1), a marker for transcriptionally permissive chromatin, at the <jats:italic>Arc<\/jats:italic> locus, but not any long\u2010lasting change in the phosphorylation of upstream transcription factor <jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content>. Furthermore, the increase in H3K4me1 at the <jats:italic>Arc<\/jats:italic> locus requires dopamine receptor signaling, and the priming of <jats:italic>Arc<\/jats:italic> expression correlates with the dopaminergic innervation pattern in the frontal cortex. Together, our results demonstrate that developmental exposure to psychostimulant amphetamine induces long\u2010lasting chromatin changes and primes activity\u2010dependent <jats:italic>Arc<\/jats:italic> gene induction. These findings reveal the molecular targets of psychostimulant during perinatal development that may contribute to long\u2010term psychiatric risks.<\/jats:p>","DOI":"10.1002\/dneu.22660","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T18:19:27Z","timestamp":1544638767000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Developmental Exposure to Psychostimulant Primes Activity\u2010dependent Gene Induction in Frontal Cortex"],"prefix":"10.1002","volume":"79","author":[{"given":"Yizhou","family":"Ye","sequence":"first","affiliation":[{"name":"Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health National Institutes of Health Bethesda MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health National Institutes of Health Bethesda MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health National Institutes of Health Bethesda MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surjeet","family":"Mastwal","sequence":"additional","affiliation":[{"name":"Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health National Institutes of Health Bethesda MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-5417","authenticated-orcid":false,"given":"Kuan Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Unit on Neural Circuits and Adaptive Behaviors, National Institute of Mental Health National Institutes of Health Bethesda MD 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Neuroteratology and Animal Modeling of Brain Disorders","volume":"29","author":"Archer T.","year":"2016","journal-title":"Current Topics in Behavioral Neurosciences"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(91)90179-X"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)81056-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1337"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.03.006"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3864-08.2008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.01.038"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.05.022"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1001\/jama.1989.03420120079030","article-title":"Temporal patterns of cocaine use in pregnancy: perinatal outcome","volume":"261","author":"Chasnoff I.J.","year":"1989","journal-title":"JAMA"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.01.014"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10524"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.31.060407.125631"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12929"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.02.009"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.201327.112"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_405"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700866114"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(93)90001-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht035"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902690105"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0806518106"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09033"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.154"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2143"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389000500115"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-017-0015-6"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.044"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2018.00023"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00100"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1114-14.2014"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3080-12.2012"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2018811"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.004"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80125-7"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.018"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5575-08.2009"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.024"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12975"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0167-14.2014"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135535"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(92)90640-S"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2708"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2218"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2015.07.006"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2611"},{"key":"e_1_2_6_47_1","unstructured":"Substance Abuse and Mental Health Services Administration. (2012)Treatment Episode Data Set (TEDS) 2000\u20102010 National Admissions to Substance Abuse Treatment Services. DASIS Series S\u201061."},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.010"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112070"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2598"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(98)00248-4"},{"issue":"1124","key":"e_1_2_6_52_1","first-page":"e1127","article-title":"The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility","volume":"98","author":"Wall M.J.","year":"2018","journal-title":"Neuron"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.038"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.154"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.03.2104"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005744"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10805"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5746-12.2013"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2018.1"},{"key":"e_1_2_6_60_1","first-page":"3600","article-title":"Dopamine is Required for Activity\u2010Dependent Amplification of Arc mRNA in Developing Postnatal Frontal Cortex","volume":"27","author":"Ye Y.","year":"2017","journal-title":"Cerebral Cortex"}],"container-title":["Developmental Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dneu.22660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T23:20:35Z","timestamp":1694474435000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dneu.22660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/dneu.22660"],"URL":"https:\/\/doi.org\/10.1002\/dneu.22660","archive":["Portico"],"relation":{},"ISSN":["1932-8451","1932-846X"],"issn-type":[{"type":"print","value":"1932-8451"},{"type":"electronic","value":"1932-846X"}],"subject":[],"published":{"date-parts":[[2018,12,19]]},"assertion":[{"value":"2018-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}