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Gradients of EphA receptors in the retina and ephrin\u2010As in the superior colliculus (SC) pattern the anteroposterior axis of the retinocollicular map, but whether they are involved in map plasticity after injury is unknown. Partial damage to the caudal SC at birth creates a compressed, complete retinotopic map in the remaining SC without affecting visual response properties. Previously, we found that the gradient of ephrin\u2010A expression in compressed maps is steeper than normal, suggesting an instructive role in compression. Here we measured EphA5 mRNA and protein levels after caudal SC damage in order to test the hypothesis that changes in retinal EphA5 expression occur that are complementary to the changes in collicular ephrin\u2010A expression.  We find that the nasotemporal gradient of EphA5 receptor expression steepens in the retina and overall expression levels change dynamically, especially in temporal retina, supporting the hypothesis. This change in receptor expression occurs after the change in ephrin\u2010A ligand expression. We propose that changes in the retinal EphA5 gradient guide recovery of the retinocollicular projection from early injury. This could occur directly through the change in EphA5 expression instructing retino\u2010SC map compression, or through ephrin\u2010A ligand signaling instructing a change in EphA5 receptor expression that in turn signals the retinocollicular map to compress. Understanding what molecular signals direct compensation for injury is essential to developing rehabilitative strategies and maximizing the potential for recovery.<\/jats:p>","DOI":"10.1002\/dneu.22675","type":"journal-article","created":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T16:31:38Z","timestamp":1553704298000},"page":"252-267","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic Alterations of Retinal EphA5 Expression in Retinocollicular Map Plasticity"],"prefix":"10.1002","volume":"79","author":[{"given":"Qi","family":"Cheng","sequence":"first","affiliation":[{"name":"Neuroscience Institute Georgia State University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Graves","sequence":"additional","affiliation":[{"name":"Department of Biology Georgia State University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-7437","authenticated-orcid":false,"given":"Sarah L.","family":"Pallas","sequence":"additional","affiliation":[{"name":"Neuroscience Institute Georgia State University Atlanta Georgia"},{"name":"Department of Biology Georgia State University Atlanta Georgia"},{"name":"Department of Biology University of Massachusetts Amherst Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_15_2_1","unstructured":"Balmer T.S. 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