{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:53:29Z","timestamp":1747148009191,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["103852"],"award-info":[{"award-number":["103852"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Developmental Neurobiology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Axon growth rate from different populations of sensory neurons is correlated with the distance they have to grow to reach their targets in development: neurons with more distant targets extend axons at intrinsically faster rates. With growth of the embryo, later\u2010born neurons within each population have further to extend their axons to reach their targets than early\u2010born neurons. Here we examined whether the axon growth rate is related to birth date by studying the axon growth from neurons that differentiate in vitro from precursor cells isolated throughout the period of neurogenesis. We first showed that neurons that differentiated in vitro from different precursor cell populations exhibited differences in axon growth rate related to in vivo target distance. We then examined the axon growth rate from neurons that differentiate from the same precursor population at different stages throughout the period of neurogenesis. We studied the epibranchial placode precursors that give rise to nodose ganglion neurons in the chicken embryo. We observed a highly significant, threefold difference in axon growth rate from neurons that differentiate from precursor cells cultured early and late during the period of neurogenesis. Our findings suggest that intrinsic differences in axon growth rate are correlated with the neuronal birth date.<\/jats:p>","DOI":"10.1002\/dneu.22743","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T21:21:07Z","timestamp":1586899267000},"page":"126-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Initial axon growth rate from embryonic sensory neurons is correlated with birth date"],"prefix":"10.1002","volume":"80","author":[{"given":"Anthony R.","family":"Horton","sequence":"first","affiliation":[{"name":"School of Biosciences Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-8176","authenticated-orcid":false,"given":"Alun M.","family":"Davies","sequence":"additional","affiliation":[{"name":"School of Biosciences Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0378"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1242\/dev.120.6.1573","article-title":"The survival of NGF\u2010dependent but not BDNF\u2010dependent cranial sensory neurons is promoted by several different neurotrophins early in their development","volume":"120","author":"Buj\u2010Bello A.","year":"1994","journal-title":"Development"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001630407"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001660406"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1242\/dev.101.2.185","article-title":"Molecular and cellular aspects of patterning sensory neurone connections in the vertebrate nervous system","volume":"101","author":"Davies A. 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